The finding that potassium oxamate inhibits glycolysis by ascites tumor cells in vitro, without inhibiting oxidative metabolism (I), indicated that oxamate might be applied to the study of the role of glycolysis in tumor growth in viva. If, as Warburg (2, 3) states, tumor cells derive much of their energy for survival and growth from glycolysis, then the inhibition of glycolysis in tumor-bearin...

Previous experimental evidence indicates that some cancer cells have an alternative glycolysis pathway with net zero ATP production, implying that upregulation of glycolysis in these cells may not be related to the generation of ATP. Here we use a genome-scale model of human cell metabolism to investigate the potential metabolic alterations in cells using net zero ATP glycolysis. We uncover a n...

That slices of tumor tissue will produce large amounts of lactic acid has been well known since the early studies in Warburg's laboratory in 192430 (10, 20). That tumor glycolysis involves the same intermediate pathway as found in normal tissues has, however, been frequently questioned, perhaps most recently by Salter who re-emphasized at the Hershey Conference on Intracellular Enzymes in Norma...

That slices of tumor tissue will produce large amounts of lactic acid has been well known since the early studies in Warburg's laboratory in 192430 (10, 20). That tumor glycolysis involves the same intermediate pathway as found in normal tissues has, however, been frequently questioned, perhaps most recently by Salter who re-emphasized at the Hershey Conference on Intracellular Enzymes in Norma...

That slices of tumor tissue will produce large amounts of lactic acid has been well known since the early studies in Warburg's laboratory in 192430 (10, 20). That tumor glycolysis involves the same intermediate pathway as found in normal tissues has, however, been frequently questioned, perhaps most recently by Salter who re-emphasized at the Hershey Conference on Intracellular Enzymes in Norma...

That slices of tumor tissue will produce large amounts of lactic acid has been well known since the early studies in Warburg's laboratory in 192430 (10, 20). That tumor glycolysis involves the same intermediate pathway as found in normal tissues has, however, been frequently questioned, perhaps most recently by Salter who re-emphasized at the Hershey Conference on Intracellular Enzymes in Norma...

Glycolysis is highly upregulated in head and neck squamous cell carcinoma (HNSCC). HNSCC glycolysis is an important contributor to disease progression and decreases sensitivity to radiation or chemotherapy. Despite therapeutic advances, the survival rates for HNSCC patients remain low. Understanding glycolysis regulation in HNSCC will facilitate the development of effective therapeutic strategi...

Giardia lamblia is an early branching eukaryotic microorganism that derives its metabolic energy primarily from anaerobic glycolysis. In most organisms, glycolysis is catalyzed by pyruvate kinase (PK), allowing the generation of two ATP molecules from one molecule of pyruvate. Giardia has both PK and pyrophosphate-dependent pyruvate phosphate dikinase (PPDK), which catalyzes the generation of f...

Aerobic glycolysis is essential for tumor growth and survival. Activation of multiple carcinogenic signals contributes to metabolism reprogramming during malignant transformation of cancer. Recently nitric oxide has been noted to promote glycolysis but the mechanism remains elusive. We report here the dual role of nitric oxide in glycolysis: low/physiological nitric oxide (≤ 100 nM) promotes gl...

Osteoarthritis (OA) is a degenerative joint disease characterized by low-grade inflammation and high levels of clinical heterogeneity. Aberrant chondrocyte metabolism response to changes in the inflammatory microenvironment may play key role cartilage degeneration OA progression. Under conditions environmental stress, chondrocytes tend adapt their microenvironmental shifting from one metabolic ...