The failure of pancreas transplantation to normalize plasma glucagon concentration and insulin: glucagon balance in portal blood has recently been demonstrated on streptozotocin-diabetic rats. The same experimental model was used in the present study to examine the effect of pancreas transplantation on liver carbohydrate metabolism. Twenty weeks after pancreas transplantation, the left hepatic ...

Although the dermatophytes are common fungal pathogens, very little is known concerning their metabolic systems. Biochemical studies with this group have been limited primarily to the nutritional requirements (Robbins et al., 1942; Schopfer and Blumer, 1943; Robbins and Ma, 1945; Georg, 1950; Benham, 1953; Silva, 1953; and Silva and Benham, 1954) and the demonstration of various extracellular e...

An unbiased screen for genes that can immortalize mouse embryonic fibroblasts identified the glycolytic enzyme phosphoglycerate mutase (PGM). A 2-fold increase in PGM activity enhances glycolytic flux, allows indefinite proliferation, and renders cells resistant to ras-induced arrest. Glucosephosphate isomerase, another glycolytic enzyme, displays similar activity and, conversely, depletion of ...

tissues form a rational basis for the development of new cancer chemotherapeutic agents. These differences have been primarily uncovered and studied in rodent tumors and it seems essential to validate or invalidate the extra polation from rodent to human tumors by similar studies in human tumors (16). Ever since Warburg (18) reported the observation of a high rate of aerobic glycolysis in most ...

This study elucidates the potential of the plant extract of Phoenix dactylifera and Zingiber officinal plantsin treating Schistosoma mansoni infected mice. The parasitological parameters, worm burden/mouse, number of ova/g tissue in the liver and intestine and the developmental stages of ova in infected treated mice were determined. In addition, glycolytic enzymes,liver function enzymes and his...

The cytosolic glyceraldehyde-3-phosphate dehydrogenase (GAPDH, EC 1.2.1.12, GapC) plays an important role in glycolysis by providing the cell with ATP and NADH. Interestingly, despite its glycolytic function in the cytosol, GAPDH was reported to possess additional non-glycolytic activities, correlating with its nuclear, or cytoskeletal localization in animal cells. In transiently transformed me...