Glycyrrhiza glabra, commonly known as licorice, is a popular herbal supplement used for the treatment of chronic inflammatory conditions and as sweetener in the food industry. This species contains a myriad of phytochemicals including the major saponin glycoside glycyrrhizin (G) of Glycyrrhetinic acid (GA) aglycone. In this study, 2D-ROESY NMR technique was successfully applied for distinguishi...

BACKGROUND The increasing use of complementary and alternative medicine (CAM) has kindled the need for scientific evaluation of the mechanism of action of CAMs. Although, licorice, a common ingredient in many Traditional Chinese medicine (TCM) has attracted great attention for its antitumor and immunomodulatory activities, the mechanism of action of its polysaccharides is still unclear. Here we...

From the roots of Glycyrrhiza uralensis, two new pterocarpenes, glycyrrhizol A (1) and glycyrrhizol B (2), along with four known isoflavonoids, 5-O-methylglycryol (3), isoglycyrol (4), 6,8-diisoprenyl-5,7,4'-trihydroxyisoflavone (5), and gancaonin G (6), were isolated using a bioassay-guided fractionation method. The structures of the new compounds (1and 2) were elucidated by spectroscopic data...

Licorice ( Glycyrrhiza uralensis Fisch) is a natural plant resource widely used as food and herbal medication in China. Glycycoumarin (GCM) major coumarin licorice that possesses several biological activities. However, little known about its pharmacokinetic profile. The present study aimed to describe the oral absorption, tissue distribution, excretion of GCM rats. Free (parent drug) and/or tot...

Glycyrrhiza uralensis Fisch. (G. uralensis) is one of the most widely used herbal medicines for the treatment of cough, spasms, pain, inflammation and low immunity This study was designed to enrich total flavonoids (TFF) from G. uralensis and investigate the anti-inflammatory activity of TFF. The anti-inflammatory activity was evaluated by inflammatory models of dimethylbenzene (DMB)-induced ea...

Glycyrrhiza uralensis Fisch. (G. uralensis) is one of the most widely used herbal medicines for the treatment of cough, spasms, pain, inflammation and low immunity This study was designed to enrich total flavonoids (TFF) from G. uralensis and investigate the anti-inflammatory activity of TFF. The anti-inflammatory activity was evaluated by inflammatory models of dimethylbenzene (DMB)-induced ea...