My research interests concern mainly the study of the modes of action of metal compounds as anticancer agents and the development of novel metal-based chemical entities with possible biological applications. Besides synthetic inorganic chemistry and structural characterization of new metal complexes (mainly gold coordination and organometallic compounds), we strongly focus on an intensive biolo...

The effect of two gold(I) compounds on stability of lysosomes in vitro was studied. Lysosomes from homogenates of rat kidney cortex were isolated by differential centrifugation. These lysosomes were incubated at 37 degrees C with widely varied concentrations of sodium aurothiomalate and sodium aurothiosulphate for 5, 35, and 65 minutes. Acid phosphatase activities were measured and used as an i...

A series of gold(III) complexes supported by pyridine-based bis(amidate), bis(carboxylate), and bis(iminothiolate) substituents is reported. These compounds represent rare examples of pincer-ligated gold(III) centers with multiple anionic heteroaom donors. Reactivity and electrochemical studies demonstrate the stability of these compounds and the marked difference in reduction potentials with v...

1S.1 General Principles 15.1.1 The chemistry of gold compounds Gold is the most noble of all the metals and this .is the key to both its eternal romance and its many practical uses in industry. It is the only metal, for example, that is not attacked in air or water by either oxygen or sulphur, and its durability under the most corrosive conditions has led to its widespread use in coinage and je...