The detection of dopamine in a highly sensitive and selective manner is crucial for the early diagnosis of a number of neurological diseases/disorders. Here, a report on a new platform for the electrochemical detection of dopamine with a considerable accuracy that comprises a 3D porous graphene oxide (pGO)/gold nanoparticle (GNP)/pGO composite-modified indium tin oxide (ITO) is presented. The p...

The goal of this research is to know structural and electrical properties gold nanoparticle (GNP) through ab initio molecular dynamic (AIMD) method. Structural are explained by the study coordination number, bond angle distribution, radial distribution function. Electrical band structure density states. GNP samples used in liquid, amorph, icosahedral. main software for AIMD numerical calculatio...

We studied the electrochemical properties of gold nanoparticles (GNPs) and their complexes with proteins using square-wave voltammetry. Effect of the nanoparticle size and detection procedure was explored upon the oxidation of GNPs on a glassy carbon electrode (GCE). For pre-characterized GNPs of 13, 35 and 78 nm diameter, the oxidation peak potential was +0.98, +1.03 and +1.06 V vs. Ag/AgCl, r...

We report a rapid and highly sensitive approach based on gold-nanoparticle-decorated silica nanorods (GNP-SiNRs) label and lateral-flow strip biosensor (LFSB) for visually detecting proteins. Owing to its biocompatibility and convenient surface modification, SiNRs were used as carriers to load numerous GNPs, and the GNP-SiNRs were used as labels for the lateral-flow assay. The LFSB detection li...

Abstract Directional strain sensing is essential for advanced sensor applications in the field of human‐machine interfaces and healthcare. Here, angle dependent anisotropic sensitivity caused by charge carriers percolating through cross‐linked gold nanoparticle (GNP) networks studied these versatile materials are used fabrication wearable triaxial pulse gesture sensors. More specifically, respo...

Herein, a double-stranded (ds) DNA microarray-based resonance light scattering (RLS) assay with multifunctional gold nanoparticle (GNP) probes has been developed for studying restriction endonuclease functionality and inhibition. Because of decreasing significantly melting temperature, the enzyme-cleaved dsDNAs easily unwind to form single-stranded (ss) DNAs. The ssDNAs are hybridized with mult...

For the past two decades, gold nanoparticles (GNPs) have been investigated as a radiosensitizing agent for radiation therapy. Many theoretical studies shown that GNPs increase dose deposition keV photon irradiation, both at macro and nano-scales, due to high photon-gold interaction probability. We studied by Monte Carlo simulations production of radiolysis chemical products (O•H H2O2) following...

Accurate and effective diagnosis individualized management of gout can be potentially achieved by detecting uric acid (UA) xanthine (XT) simultaneously using an easy-to-use method. Herein, we report simultaneous detection UA XT a 3-dimensional (3D) macroporous gold nanoparticle-incorporated reduced graphene oxide–carbon nanotube nanocomposite (GNP/rGO-CNT). The GNP/rGO-CNT was simply prepared o...

Limited efficacy of current first-line treatment for leukemia calls attention for further development of efficient strategies. Recently, much attention has been given to nanoparticle-based drug delivery systems loaded with dual drugs to improve current disease therapies by overcoming toxicity. In the present study, we document to explore an approach to conjugate gold nanoparticles (GNPs) with p...

Inhibition of the interaction between p53 and HDM2 is an effective therapeutic strategy in cancers that harbor a wild-type p53 protein such as retinoblastoma (RB). Nanoparticle-based delivery of therapeutic molecules has been shown to be advantageous in localized delivery, including to the eye, by overcoming ocular barriers. In this study, we utilized biocompatible gold nanoparticles (GNPs) to ...