Background To compare two different gonadotropin preparations, human menopausal gonadotropin (hMG) and recombinant follicle-stimulating hormone (rFSH), combined with clomiphene citrate (CC) in women with unexplained infertility undergoing intrauterine insemination (IUI). MaterialsAndMethods In this prospective clinical trial, couples prepared for IUI cycles were randomly allocated to two groups...

It is now known that removal of the olfactory bulbs increases basal gonadotropin secretion and prevents short-photoperiod-induced testicular regression in Syrian hamsters. The experiments described in the present paper were an attempt to determine which neuronal systems associated with the olfactory bulbs are responsible for this influence on the reproductive neuroendocrine axis. In the first e...

introduction: gonadotropin inhibitory hormone (gnih) has been known as a key inhibitor of the secretion of gonadotropin releasing hormone (gnrh). ewe has estrous cycles comprising of follicular and luteal phases. follicular phase is in turn divided into proestrous and estrous phases. blood level of lh increases in follicular and decreases in luteal phases. the aim of the present study was to ev...

this study explored the effects of gnrh agonist (gnrha) immunity on expression of fshr mrna in pituitary and fshr protein in uteri, and also confirmed its efficacy on uterine development. 42 prepuberty and non cyclic ewes were assigned to 6 experimental groups (eg) during anestrus season. animals in eg-i, eg-ii and eg-iii were subcutaneously injected with 200, 300 and 400 μg alarelin antigens (...

Premature activation of the hypothalamic-pituitary-gonadal (HPG) axis manifests as gonadotropin-dependent precocious puberty. The mechanisms behind HPG activation are complex and a clear etiology for early activation is often not elucidated. Though collectively uncommon, the neoplastic and developmental causes of gonadotropin-dependent precocious puberty are very important to consider, as a del...

Objective. Determine which factors predict multiple pregnancy in gonadotropin-intrauterine insemination cycles so that cancellation criteria might be developed. Study Design. Retrospective chart review of all patients undergoing gonadotropin-intrauterine insemination over a continuous 36 month period. Results. No factors examined were able to predict the occurrence of multiple pregnancy. Conclu...

The gonadotropin hypothesis proposes that elevated serum gonadotropin levels may increase the risk of epithelial ovarian cancer (EOC). We have studied the effect of treating EOC cell lines (OV207 and OVCAR-3) with FSH or LH. Both gonadotropins activated the mitogen-activated protein kinase (MAPK)/extracellular signal-regulated kinase 1/2 (ERK1/2) pathway and increased cell migration that was in...

BACKGROUNDS In vitro fertilization involves high dosage gonadotropin stimulation, which apparently has some negative impact on follicular endocrine function. As chorionic gonadotropin stimulation has been shown to increase the blood-follicular permeability in animal models, this raises the question if such an effect also applies to gonadotropins in humans, possibly affecting the endocrine folli...

The role of RNA synthesis was investigated in the action of chorionic gonadotropin on ovaries of immature rats. Chorionic gonadotropin accelerates the ovarian incorporation of [3H]uridine in uivo into rapidly labeled nuclear RNA within 10 min after hormone injection. Analysis of the RNA base composition, expressed as base ratio (A + U):(G + C), shows that hormonal stimulation of the rate of [3H...

background: clomiphene citrate (cc) an agonist and antagonist of estrogen, is the first line treatment in ovarian stimulation. anti-estrogenic effect of cc in endometrial thickness and cervical mucus has negative effect on pregnancy rate. letrozole is an aromatase inhibitor has been seen that has acceptable pregnancy rate compared to cc. objective: the aim of this study was to compare the effic...