Without adaptive immunity, invertebrates have evolved innate immune systems that react to antigens on the surfaces of pathogens. These defense mechanisms are included in horseshoe crab hemocytes’ cellular responses Secretory granules, large (L) and small (S), found hemocytes. Once invasion pathogens is present, these granules release their contents through exocytosis. Recent data biochemistry i...

In post-ganglionic sympathetic neurons, biochemical and electron-microscopical evidence indicate that noradrenaline is stored within granules which, although smaller, resemble adrenal medullary chromaffin granules in some respects. This resemblance between neuronal and adrenal medullary granules has been extended by immunological and enzymic investigations which show that sympathetic nerve gran...

Deconvolution wide-field fluorescence microscopy and single-particle tracking were used to study the three-dimensional mobility of single secretory granules in live PC12 cells. Acridine orange-labeled granules were found to travel primarily in random and caged diffusion, whereas only a small fraction of granules traveled in directed fashion. High K(+) stimulation increased significantly the per...

The concept of an effective field in intergranular medium is used to describe the hysteresis magnetoresistance granular HTSCs. This a superposition external magnetic and induced by moments superconducting granules. moment granules contributed shielding currents trapped flux. We studied analyzed effect flux on magnetoresistance. It has been experimentally shown that dependence residual resistanc...

We examined subcellular histamine localizations in purified human basophils that were stimulated to degranulate with FMLP using an ultrastructural enzyme-affinity technique. Basophils were collected at early (0, 20 seconds, 1 minute) and late (10 minutes to 6 hours) time points poststimulation and were prepared for routine ultrastructural and diamine oxidase-gold (DAO-gold) cytochemical analysi...

Leukemic myeloblasts containing abnormal granules were studied with ultrastructural, cytochemical, and thymidine labeling techniques to evaluate defects in granulogenesis and proliferation. Giant granules (1 to 3 micron in diameter) and Auer rods were observed in leukemic cells from two patients, and only rarely were both abnormal granule types observed in the same cell. The lysosomal origin of...