BACKGROUND Granulocyte transfusion has been proposed as a bridging therapy for patients with prolonged periods of chemotherapy-induced neutropenia, who suffer from severe fungal and bacterial infections. To recover, adequate numbers of granulocytes are required when the patients are refractory to standard treatment. The aim of this study was to assess the functional characteristics and efficacy...

OBJECTIVES/HYPOTHESIS Granulocyte/macrophage colony-stimulating factor is important in the pathogenesis of acute and chronic inflammatory disease. We hypothesized that granulocyte/macrophage colony-stimulating factor plays a pivotal role in middle ear inflammation and that neutralization of granulocyte/macrophage colony-stimulating factor would inhibit neutrophil migration into the middle ear a...

I NFECTION is a major cause of death in acute leukemia.’ Although the phagocytic activity of the mature granulocyte in the leukemic patient appears to be unimpaired,2” numerous studies have demonstrated a defect in granulocyte mobilization to an inflammatory site.4#{176}The response is both delayed and diminished. While granulocytopenia, either secondary to marrow replacement or to chemotherapy...

Inhibition of complement-mediated granulocyte aggregation has recently been proposed as a mechanism of action of high-dose corticosteroids in shock states. Such inhibition may be effected through alteration of receptor function. Methylprednisolone inhibits binding of the synthetic chemotaxin f-methionine-leucine-phenylalanine (FMLP) to its surface receptor on granulocytes in a dose-dependent ma...

BACKGROUND AND OBJECTIVE Mucosal inflammatory responses are orchestrated largely by pro-inflammatory chemokines. The chemokine granulocyte chemotactic protein 2 (CXCL6) is involved in neutrophil recruitment and migration. Previous studies have shown that granulocyte chemotactic protein 2 is up-regulated during mucosal inflammation (e.g. in inflammatory bowel disease), similarly to the functiona...

Granulocyte chalone obtained from media conditioned by rat granulocytes was tested on normal and vinblastine treated regenerating mouse marrow placed in an in vivo diffusion chamber culture system. Raw granulocyte chalone when injected several times during the early phase of culture significantly altered the cellular growth pattern as well as the parent-progeny relationships of both normal and ...

Granulocyte concentrates collected from normal donors are necessarily stored for varying intervals up to the time of transfusion. However, information regarding the fate of collected cells and the optimal mode of storage in vitro in the interval between collection and transfusion is far from complete. We studied granulocyte function during preservation of granulocyte concentrates for up to 72 h...

It has been suggested, on the basis of impaired granulocyte migration to skin windows, that there is a fundamental granulocyte defect in Crohn's disease. In vitro tests of granulocyte function have, however, failed to confirm this. We have studied granulocyte migration to inflamed bowel in Crohn's disease using a new approach which utilises dynamic gamma camera imaging after injection of 111In ...