Angelman syndrome is a neurodevelopmental disorder caused by mutations in the maternally inherited UBE3A gene, which encodes a ubiquitin ligase. Greer et al. (2010) now identify a UBE3A substrate called Arc that promotes endocytosis of neuronal AMPA receptors, providing insight into synaptic defects that may underlie the cognitive deficits in Angelman syndrome.

This paper qualitatively describes the deprivation under different coupling situations of two-dimensional indicators and then establishes the twodimensional coupling model on social deprivation, using the social welfare function approach and Foster-Greer-Thorbecke α P method. Finally, this paper applies the model to evaluate the social deprivation of 31 provinces in China under the coupling sta...

Xiaoyue Ni, Stefanos Papanikolaou, 3, 4 Gabriele Vajente, Rana X Adhikari, and Julia R. Greer Division of Engineering and Applied Sciences, California Institute of Technology, Pasadena, CA 91125 Department of Mechanical Engineering, Johns Hopkins University, 3400 N Charles St, Baltimore, MD 21218. Department of Mechanical and Aerospace Engineering, West Virginia University, 395 Evansdale Dr, Mo...

nigeria represents one of the paradoxes of development in which case the nation is rich but her people are poor. this study examines the rate of poverty among rural households in south western, nigeria. a random multistage sampling was employed for the study. ekiti and osun states were randomly selected from the six states in south-western nigeria. this was followed by random selection of two l...

171. Impact of Rapid Bloodstream Pathogen Identification in Hospitalized Patients Matthew Maslonka, MD; Alison G. Freifeld, MD; Mark E. Rupp, MD; Devon Greer, PharmD; Robbe Peetz, PA; Elizabeth Lyden, MS; Paul D. Fey, PhD; Trevor C. Van Schooneveld, MD; Division of Infectious Diseases, University of Nebraska Medical Center, Omaha, NE; Pharmacy and Nutrition, Nebraska Medical Center, Omaha, NE; ...

Disorders of the thyroid gland commonly produce mental changes, albeit these are usually minor disturbances. The neurotic symptoms of thyrotoxicosis like anxiety and irritability are prosaic and may antedate physical complaints. There is a plethora of literature on the psychosis associated with myxoedema but a paucity of information on hyperthyroidism. Reviews by Greer and Parsons I and Whybrow...