OBJECTIVE To observe the effects of matrine on proliferation and apoptosis of human renal cell carcinoma cell line GRC-1 in vitro, and to explore its mechanism. METHODS The human renal cell carcinoma cell line GRC-1 was treated with matrine of different concentrations for 24, 48, 72 and 96 h respectively. The MTT assay was used to evaluate the cytotoxic effects of matrine on GRC-1 cells. The ...

BACKGROUND Research in 2007 showed that World Health Organization (WHO) recommendations were largely based on expert opinion, rarely used systematic evidence-based methods, and did not follow the organization's own "Guidelines for Guidelines". In response, the WHO established a "Guidelines Review Committee" (GRC) to implement and oversee internationally recognized standards. We examined the imp...

BACKGROUND Because of the insensitivity of renal cell carcinoma (RCC) to both chemotherapy and radiotherapy, surgery remains the primary approach for anticancer treatment. However, patients who do not receive timely diagnoses may not be suitable for surgery, especially in the late phase of tumor development. Thus, the discovery of novel effective treatment is of great importance. Allyl isothioc...

The residual cutting (RC) method has been proposed for efficiently solving linear equations obtained from elliptic partial differential equations. Based on the RC, we have introduced the generalized residual cutting (GRC) method, which can be applied to general sparse matrix problems. In this paper, we study the mathematics of the GRC algorithm and and prove it is a Krylov subspace method. More...

Information technology (IT) has a tremendous impact on the discipline of accounting by introducing new ways of retrieving and processing information about performance deviations and control effectiveness. This paper explores the role of IT for managing organizational controls by analyzing value drivers for particular accounting information systems that commonly run under the label of Governance...

In the presence of amine-containing sulfhydryl compounds, binding of heat-transformed cytosolic rat liver glucocorticoid receptor complex (GRC) to double-stranded calf thymus DNA-coated cellulose and to rat liver chromatin was enhanced up to 10-fold. These observations were made under conditions when a maximum of 8% of the total GRC bound to DNA in the absence of test compound. Compounds which ...

The effects of schisandrin B (Sch B), curcumin, epigallocatechin gallate (EGCG) and resveratrol on the glutathione regeneration capacity (GRC) of liver and heart tissues ex vivo were examined in relation to their protective effects against CCl4 hepatotoxicity in vivo and myocardial ischemia/reperfusion (I/R) injury ex vivo in rats. Results indicated that Sch B, but not curcumin, EGCG or resvera...

Granular computing (GrC) may be regarded as a label of theories, methodologies, techniques, and tools that make use of granules, i.e., groups, classes, or clusters of a universe, in the process of problem solving. The main objective of this paper is to discuss basic issues of GrC, with emphasis on the construction of granules and computation with granules. After a brief review of existing studi...

BACKGROUND The first peak of the knee adduction moment curve during walking has been shown to be a good clinical surrogate measure of medial tibiofemoral joint loading and osteoarthritis. Defining the relative contributions of the variables that dictate the knee adduction moment, such as center of mass, center of pressure, vertical ground reaction force, and knee adduction angle (i.e. lower lim...

objectives: foot and ankle problems are common complications in rheumatoid arthritis disease. gait pattern such as normal foot and ankle rocker is impaired in patients with rheumatoid arthritis. rocker sole as an external shoe modification is commonly prescribed in this pathology. the aim of this study was to investigate the effect of rocker shoe on vertical ground reaction force parameters dur...