AS OF MAY 30, 2012, THE CATALOG OF PUBLISHED GEnome-wide association studies (GWAS) lists an impressive 1269 GWAS, covering a broad spectrum of conditions including Alzheimer disease, breast cancer, and human immunodeficiency virus susceptibility. The catalog also contains studies on common traits such as height and freckles, as well as responses to drugs for various medical conditions. It is d...

Recent advances in high-throughput genotyping technologies have enabled us to conduct a genome-wide association study (GWAS) on a large cohort. However, analyzing millions of single nucleotide polymorphisms (SNPs) is still a difficult task for researchers conducting a GWAS. Several difficulties such as compatibilities and dependencies are often encountered by researchers using analytical tools,...

AIMS To understand the role of ancestral genomic background in substance dependence (SD) genome-wide association studies (GWAS), we analyzed population diversity at genetic loci associated with SD traits and evaluated its effect on GWAS outcomes. MATERIALS & METHODS We investigated 24 genes with variants associated with SD by GWAS; and 82 loci with putative subordinate roles with respect to S...

BACKGROUND The biomedical community benefits from the increasing availability of genomic data to support meaningful scientific research, e.g., Genome-Wide Association Studies (GWAS). However, high quality GWAS usually requires a large amount of samples, which can grow beyond the capability of a single institution. Federated genomic data analysis holds the promise of enabling cross-institution c...

There is a large gap between genomewide association studies (GWAS) and developing markers that can be used in marker-assisted selection (MAS) schemes for cultivar improvement. This study prototype using segregating single nucleotide polymorphisms (SNPs) panicle architecture grain shape traits identified by GWAS the Rice Diversity Panel-1 colocalized QTL regions revealed linkage mapping Estrela ...

We study a class of Z-graded algebras introduced by Bell and Rogalski. Their construction generalizes in large part that rank one generalized Weyl (GWAs). establish certain ring-theoretic properties these their connection to GWAs. classify the simple weight modules infinite orbit case provide partial classification orbits finite order.

As our understanding of genetics has improved, genome-wide association studies (GWAS) have identified numerous variants associated with lifestyle behaviours and health outcomes. However, what is sometimes overlooked is the possibility that genetic variants identified in GWAS of disease might reflect the effect of modifiable risk factors as well as direct genetic effects. We discuss this possibi...