BACKGROUND Paclitaxel is used in the treatment of most gynecologic malignancies. It is solubilized in Cremophor EL, a polyoxyethylated castor oil agent responsible for the high rate of paclitaxel-associated hypersensitivity reactions. Abraxane, a newer, Cremophor-free form of albumin bound paclitaxel has demonstrated an activity and an improved toxicity profile in breast and lung cancers. CAS...

Synchronous cancer is referred to two or more histological distinct malignancies diagnosed during the same hospital admission. Globally more than 1 million people get colorectal cancer yearly resulting in about 0.5 million deaths. Vulvar cancer is the fourth most common gynecologic cancer (following the corpus uterine cancer, cancer of ovary and cervix) and comprises only 4 percent of malignanc...

synchronous cancer is referred to two or more histological distinct malignancies diagnosed during the same hospital admission. globally more than 1 million people get colorectal cancer yearly resulting in about 0.5 million deaths. vulvar cancer is the fourth most common gynecologic cancer (following the corpus uterine cancer, cancer of ovary and cervix) and comprises only 4 percent of malignanc...

It was not until 1951 that Kalk and Bruhl reported their experience with purpose-specific instruments employed in over 2,000 patients.[3] Initially used for tubal sterilization, evaluation for ectopic pregnancy, and treatment of endometriosis, the role of laparoscopy was expanded by Semm to include appendectomy in 1983.[4] This set in motion a decade marked by advances in endoscopic procedures ...

Endometrial cancer is the most common female genital tract cancer in the United States. The majority of cases are confined to the uterus. Treatment of organ-confined uterine cancer usually comprises total abdominal hysterectomy and bilateral salpingo-oophorectomy (TAH/BSO). In 1988, clinical staging of endometrial cancer was replaced with surgical staging because of inaccuracies associated with...

The article by Kim et al is a comprehensive summary of several decades of research in the management of cervical and vulvar cancer. It describes the current status of treatment and possible future trials. Surgical Staging For the management of cervical cancer, two issues need to be further addressed. The first is surgical staging of cervical cancer. For decades it has been known that nodal meta...

Two things become apparent to the reader of this excellent article. First, the National Cancer Institute clearly had great foresight in 1970, when they began funding the Gynecologic Oncology Group (GOG) so that phase I, II, and III trials could be conducted in a systematic manner. Second, the authors have written a thorough review of over 3 decades of research into the biology and clinical aspe...