نتایج جستجو برای: hadhb
تعداد نتایج: 36 فیلتر نتایج به سال:
OBJECTIVE miR-33 has emerged as an important regulator of lipid homeostasis. Inhibition of miR-33 has been demonstrated as protective against atherosclerosis; however, recent studies in mice suggest that miR-33 inhibition may have adverse effects on lipid and insulin metabolism. Given the therapeutic interest in miR-33 inhibitors for treating atherosclerosis, we sought to test whether pharmacol...
The role of Sirtuins in brain function is emerging, yet little is known about SIRT5 in this domain. Our previous work demonstrates that protein kinase C epsilon (PKCε)-induced protection from focal ischemia is lost in SIRT5-/- mice. Thus, metabolic regulation by SIRT5 contributes significantly to ischemic tolerance. The aim of this study was to identify the SIRT5-regulated metabolic pathways in...
Abstract Background Muscle is the predominant portion of any meat product, and growth performance product quality are core modern breeding. The embryonic period highly critical for muscle development, number, shape structure fibers determined at stage. Herein, we performed transcriptome analysis to reveal law development in stage Chengkou Mountain Chicken days (E) 12, 16, 19, 21. Results Diamet...
Hypothyroidism is an important endocrine complication of major thalassemia. It should be prevented because of its effects on patients’ growth and development. The aim of this study was to determine the effect of regular blood transfusion and desferal use in preventing of such complications. An observational, cross-sectional study was conducted on 185 major thalassemic adolescents in Hazrat Al...
Marked species-specific responses to agonists of the peroxisome proliferator-activated alpha receptor (PPAR alpha) have been observed in rats and dogs, two species typically used to assess the potential human risk of pharmaceuticals in development. In this study, we used primary cultured rat and dog hepatocytes to investigate the underlying mechanisms of a novel PPAR alpha and -gamma coagonist,...
Cardiovascular disease remains the leading cause of mortality in westernized countries, despite optimummedical therapy to reduce the levels of low-density lipoprotein (LDL)-associated cholesterol. The pursuit of novel therapies to target the residual risk has focused on raising the levels of high-density lipoprotein (HDL)associated cholesterol in order to exploit its atheroprotective effects. M...
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