Although alteration in the haptoglobin phenotype has been reported in patients with bladder cancer, serum haptoglobin levels have not been evaluated. We hypothesized that serum haptoglobin can be used as a biomarker. The aim of this study was to evaluate the expression of haptoglobin in bladder cancer and to determine the relationship with clinicopathological features. A total of 68 serum speci...

background: introduction: searching for an ideal marker for diagnosing neonatal infection is still an important concern in every country. there are many biomarkers reported for neonatal sepsis. haptoglobin is an acute phase reactants which rise in response to infection and injuries. in this report we discussed the efficacy of serum haptoglobin level in different cut off levels in early onset ne...

Haptoglobin is a hemoglobin-binding protein expressed by a genetic polymorphism as three major phenotypes: 1-1, 2-1, and 2-2. Most attention has been paid to determining haptoglobin phenotype as a genetic fingerprint used in forensic medicine. More recently, several functional differences between haptoglobin phenotypes have been demonstrated that appear to have important biological and clinical...

Trypanosomes are protozoan parasites of medical and veterinary importance. Trypanosoma brucei rhodesiense and Trypanosoma brucei gambiense infect humans, causing African sleeping sickness. However, Trypanosoma brucei brucei can only infect animals, causing the disease Nagana in cattle. Man is protected from this subspecies of trypanosomes by a toxic subtype of high density lipoproteins (HDLs) c...

Haptoglobin binding to haemoglobin and its isolated a and #-chains was studied by use of a highly sensitive solid-phase radiometric assay. As expected, adsorbents of haemoglobin bound '25I-labelled haptoglobin more efficiently than did adsorbents of the (achain. However, unexpectedly, adsorbents of the f-chain were found to be essentially identical with those of the a-chain in their ability to ...

The mean concentration of each of the serum protein-bound carbohydrates (hexose, hexosamine, fucose, and sialic acid) was significantly elevated in a group of 60 male schizophrenic patients. The total serum protein was elevated, ceruloplasmin was normal, and C-reactive protein was absent. Serum haptoglobin was significantly elevated. The distribution of haptoglobin types was normal. Haptoglobin...

Secreted by activated cells or passively released by damaged cells, extracellular HMGB1 is a prototypical damage-associated molecular pattern (DAMP) inflammatory mediator. During the course of developing extracorporeal approaches to treating injury and infection, we inadvertently discovered that haptoglobin, the acute phase protein that binds extracellular hemoglobin and targets cellular uptake...

Haptoglobin serves as an antioxidant by virtue of its ability to prevent hemoglobindriven oxidative tissue damage. It was recently demonstrated that an allelic polymorphism in the haptoglobin gene is predictive of the risk for numerous microvascular and macrovascular diabetic complications. Because these complications are attributed in large part to an increase in oxidative stress, a study was ...

Haptoglobin is an a2 plasma glycoprotein that forms a stable complex with hemoglobin (1-5). The complex is cleared from the plasma much more rapidly than free haptoglobin so that marked hypoor anhaptoglobinemia is a concomitant of hemolysis (6, 7). Since free hemoglobin passes readily into the urine, whereas the complex, perhaps owing to its much greater size, does not, haptoglobin may play a r...

INTRODUCTION Plasma levels of cell-free hemoglobin are associated with mortality in patients with sepsis; however descriptions of independent associations with free hemoglobin and free heme scavengers, haptoglobin and hemopexin, are lacking beyond their description as acute phase reactants. We sought to determine the association of plasma levels of endogenous free hemoglobin and haptoglobin and...