Background: Since many surveys for the prevalence of β thalassemia have been made in area with high prevalence of malaria, it is important to find out whether malaria can modify Hb A2 levels. In present study, analysis of Hb A2 level of patients with malaria and thalassemia has been done and has been compared with control group to conclude that whether Hb A2 level was affected or not. Methodolo...

We report the case of an Italian infant girl hand, in the Askenazy carriers of Hb Hafrom Polesine (Po delta region in northern sharon, Hb Hasharon is probably linked to Italy) who was heterozygous for Hb Haa normal a gene. In comparing Hb Hasharon and a-thalassemia, did not synthesharon’s behavior with that of other a size any normal HbA, and had 3% HbH on variants, particularly HbG Philadelphi...

Fetal hemoglobin (Hb F) is characteristic of the fetal development period. However, in some genetic conditions, such as hereditary persistence of fetal hemoglobin (HPFH) and delta-beta thalassemia (δβ-thalassemia), Hb F continues to be produced in adulthood. We evaluated the frequency of two mutations of HPFH, HPFH-1 and HPFH-2 African, and two mutations in δβ-thalassemia, Sicilian and Spa...

Patients with thalassemia intermedia have a mild anemia and survive without needing regular blood transfusions.1 Here we report two cases of Thai patients with β-thalassemia intermedia caused by homozygosity of hemoglobin Malay (Hb Malay; α2β219Asn-Ser)2 and compound heterozygosity of Hb Malay and hemoglobin E (Hb E; α2β226Glu-Lys). Both patients presented with a history of anemia with marked m...

Hemoglobin release test (HRT), which is established by our lab, is a new experiment to observe the re-released hemoglobin (Hb) from erythrocytes. In this study, onedimension HRT, double dimension HRT, and isotonic and hypotonic HRT were performed to observe the re-released Hb from the blood samples of normal adult, hereditary spherocytosis (HS), and α-thalassemia. The results showed that compar...

Between January 1995 and December 2005, we conducted a screening program for the presence of Hb Neapolis, a rare abnormal Hb variant, in Campania, a region in Southern Italy. Nineteen patients with Hb Neapolis in heterozygosis and six patients with a genetic compound (Hb Neapolis/beta-thalassemia) were identified. Patients with Hb Neapolis in heterozygosis showed a slight alteration in HbA2 lev...

DOI: 10.5581/1516-8484.20110128 Thalassemias are common monogenic disorders caused by partial or complete reduction synthesis of one or more globin chains.(1) The normal concentrations of fetal hemoglobin (Hb F) in adults without Hb alterations range from 0% to 1%.(2) It is known that stimulation of Hb F production is beneficial to homozygous beta-thalassemia individuals(3) and that the XmnI po...

Commercial microcolumns introduced in 1976 by Helena Laboratories ("Hb A2 Quik Column") and by Isolab, Inc. ("Quik-Sep") provide a rapid, simple, accurate method for quantitation of hemoglobin A2 (Hb A2). However, these kits cannot be used for the quantitation of Hb A2 in the presence of slow-moving variants such as Hb S. Recently, Isolab, Inc., produced a new kit ("Quik-Sep Improved Hb A2 Test...

In beta thalassemia/hemoglobin E (Hb E), abnormally high levels of oxidative stress account for accelerated senescence and increased destruction of erythrocytes. The present study aimed to investigate the role of glutathione efflux transporters, namely cystic fibrosis transmembrane conductance regulator (CFTR) and multidrug resistance-associated protein 1 (MRP1), in the control of glutathione l...