BACKGROUND Chronic mountain sickness (CMS), originally characterized by excess hemoglobin (Hb), is currently diagnosed using score-based diagnostic criteria combined with excessive erythrocytosis and clinical symptoms. However, the current criteria have limited applicability. We applied these criteria to 1,029 Chinese Han males migrated to and have been stayed at the Qinghai-Tibet plateau (3,70...

Novel magnetic Fe(3)O(4)/chitosan (CS) microspheres were prepared using magnetic Fe(3)O(4) nanoparticles and the natural macromolecule chitosan. Then, using an easy and effective hemoglobin (Hb) immobilization method, an innovative biosensor with a Fe(3)O(4)/CS-Hb-Fe(3)O(4)/CS "sandwich" configuration was constructed. This biosensor had a fast (less than 10 s) response to H(2)O(2) and excellent...

A recombinant hemoglobin containing Val beta 7 (Hb beta E7V) was engineered and expressed in yeast to evaluate amino acid specificity of the Glu beta 6-->Val mutation (Hb beta E6V) in promoting polymer formation of deoxyhemoglobin. The purified CO Hb beta E7V migrated as a single band on electrophoresis with a slightly decreased positive charge compared with CO Hb S. The oxygen affinity of Hb b...

We explore complementarity between output and environment of a quantum channel (or, more generally, CP map), making an observation that the output purity characteristics for complementary CP maps coincide. Hence, validity of the mutiplicativity/additivity conjecture for a class of CP maps implies its validity for complementary maps. The class of CP maps complementary to entanglement-breaking on...

Utilization of near-infrared spectroscopy (NIRS) in clinical exercise testing to detect microvascular abnormalities requires characterization of the responses in healthy individuals and theoretical foundation for data interpretation. We examined the profile of the deoxygenated hemoglobin signal from NIRS {deoxygenated hemoglobin + myoglobin [deoxy-(Hb+Mb)] approximately O(2) extraction} during ...

We report new photometry for 10 globular clusters in M31, observed to a uniform depth of four orbits in F5555W(V) and F814W(I) using WFPC2 on board HST. Additionally we have reanalyzed HST archival data of comparable quality, for 2 more clusters. A special feature of our analysis is the extraordinary care taken to account for the effects of blended stellar images and required subtraction of con...

The direct electrochemistry of hemoglobin (Hb) immobilized on a hexagonal mesoporous silica (HMS)-modified glassy carbon electrode was described. The interaction between Hb and the HMS was investigated using UV-Vis spectroscopy, FT-IR, and electrochemical methods. The direct electron transfer of the immobilized Hb exhibited two couples of redox peaks with the formal potentials of -0.037 and -0....

A study was carried out to determine in-tube evaporation and condensation performance of enhanced heat transfer tubes (EHT) using R410A, with the results being compared a plain tube. The test considered in evaluation include: plain, herringbone (HB) spiral (HX) microgrooves, dimple (HB/D), hydrophobic (HB/HY). Experiments evaluate were conducted at saturation 318 K, 279 K for evaporation. Mass ...

BACKGROUND AND OBJECTIVES The purpose was to evaluate changes in the left ventricular mass index (LVMi) among anemic chronic kidney disease (CKD) and end-stage renal disease (ESRD) patients treated with recombinant human erythropoietin (EPO). DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS A systematic review of the literature, reporting LVMi for patients before and after EPO therapy, was perfo...

Isolated 3H-labeled human hemoglobin alpha chains were incubated with unlabeled carbonmonoxyhemoglobin A for 72 h in 0.01 M potassium phosphate, pH 7.0, at 25 degrees C. Following separation of the free alpha chain monomers and Hb A (alpha 2 beta 2) tetramers by electrophoresis on cellulose acetate strips or by chromatography on DEAE-cellulose columns, analysis of radioactivity showed a slow tr...