نتایج جستجو برای: hbv genome cpg
تعداد نتایج: 253638 فیلتر نتایج به سال:
Abstract Background Hepatitis B virus (HBV) vaccine seroprotection rates with conventional aluminum adjuvanted recombinant HBV vaccines (HepB-alum) among people HIV (PWH) are varied. HepB-CpG, a novel vaccine, has shown higher in immunocompetent patients but is not well studied PWH. There no published studies comparing between HepB-alum and HepB-CpG The purpose of this study was to evaluate com...
Hepatitis B virus (HBV) is among the most common causes of liver cirrhosis. We report the full-genome sequences of seven molecular clones of HBV genotype A, amplified from an HBV-infected North Indian patient. This is probably the first report of the HBV genome sequencing using Ion Torrent from India.
Macrophages and B cells are activated by unmethylated CpG-containing sequences in bacterial DNA. The lack of activity of self DNA has generally been attributed to CpG suppression and methylation, although the role of methylation is in doubt. The frequency of CpG in the mouse genome is 12.5% of Escherichia coli, with unmethylated CpG occurring at approximately 3% the frequency of E. coli. This s...
context hepatitis b and hepatitis c (hbv and hcv) infections are both major causes of hepatocellular carcinoma (hcc). however, hcc caused by each of these two viruses has unique characteristics that should be studied independently to that of another one. while hbv- and hcv-related hccs share similar host and environmental risk factors such as male gender, age above 50 years old, family history ...
introduction: the hepatitis b is a viral infection that causes a big problem globally. about 2 billion people worldwide are infected and there are now about 400 million hbv-dna carriers around the world. hbv infection is the ninth cause of death worldwide and infects about 350 million new cases each year in the world. hbv-dna can be spotted in different body secretions and fluids, including ser...
The presence of hepatitis B virus (HBV) covalently closed circular DNA (cccDNA) and the permanent integration of HBV DNA into the host genome confers the risk of viral reactivation and hepatocellular carcinoma. Nucleoside/nucleotide analogs alone have little or no capacity to eliminate replicative HBV templates consisting of cccDNA or integrated HBV DNA. Recently, CRISPR/Cas9 technology has bee...
CpG islands are >200-bp stretches of DNA that have a significantly higher concentration of CpG dinucleotides than the bulk of the genome. Whereas 70%–80% of all CpG dinucleotides in the human genome are methylated, CpG islands by and large remain unmethylated (Cross and Bird 1995), with the exception of those associated with imprinted and X-linked genes (Razin and Cedar 1994). In this issue of ...
The infectivity of cloned hepatitis B viral DNA (HBV) has been tested in chimpanzees to identify a fully functional HBV genome and to assess the risk associated with its handling. Only one of two HBV DNA sequence variants tested was shown to be infectious. "Clone purified" virus of predicted nucleotide sequence was produced from the infectious HBV DNA, and the cloned viral genome was identical ...
A recombinant hepatitis B virus (HBV) expressing NanoLuc (NL) (HBV/NL) was produced by cotransfecting a plasmid containing a 1.2-fold HBV genome carrying the NL gene with a plasmid bearing a packaging-defective 1.2-fold HBV genome into a human hepatoma cell line, HepG2. We found that NL activity in HBV/NL-infected primary hepatocytes or sodium taurocholate cotransporting polypeptide-transduced ...
A striking feature of the human genome is the dearth of CpG dinucleotides (CpGs) interrupted occasionally by CpG islands (CGIs), regions with relatively high content of the dinucleotide. CGIs are generally associated with promoters; genes, whose promoters are especially rich in CpG sequences, tend to be expressed in most tissues. However, all working definitions of what constitutes a CGI rely o...
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