Hepatitis delta virus (HDV) is a subviral human pathogen that uses specific RNA editing activity of the host to produce two essential forms of the sole viral protein, hepatitis delta antigen (HDAg). Editing at the amber/W site of HDV antigenomic RNA leads to the production of the longer form (HDAg-L), which is required for RNA packaging but which is a potent trans-dominant inhibitor of HDV RNA ...

Hepatitis delta virus (HDV) infection causes the most severe form of viral hepatitis, but little is known about molecular mechanisms involved. We have recently developed an HDV mouse model based on delivery replication-competent genomes using adeno-associated vectors (AAV), which a liver pathology very similar to human disease and allowed us perform mechanistic studies. generated different AAV-...

Hepatitis delta virus (HDV) is a pathogenic RNA virus with a plant viroid-like genome structure. HDV encodes two isoforms of delta antigen (HDAg), the small and large forms of HDAg (SHDAg and LHDAg), which are essential for HDV RNA replication and virion assembly, respectively. Replication of HDV RNA depends on host cellular transcription machinery, and the exact molecular mechanism for HDV RNA...

Hepatitis delta virus (HDV) is a subviral pathogen that increases the severity of liver disease caused by hepatitis B virus. Both the small circular RNA genome and its complement, the antigenome, form a characteristic unbranched rod structure in which approximately 70% of the nucleotides are base paired. These RNAs are associated with the sole virally encoded protein, hepatitis delta antigen (H...

Hepatitis delta antigens (HDAgs) are important for the replication and assembly of hepatitis delta virus (HDV). To understand the association between HDAgs and cellular proteins and the mechanism of viral multiplication, we have studied the interaction between HDAgs and nucleolin, a major nucleolar phosphoprotein. The interaction between HDAgs and nucleolin was first demonstrated by immunofluor...

This paper proposes a machine learning based question classification method using a kernel function, Hierarchical Directed Acyclic Graph (HDAG) Kernel. The HDAG Kernel directly accepts structured natural language data, such as several levels of chunks and their relations, and computes the value of the kernel function at a practical cost and time while reflecting all of these structures. We exam...

Hepatitis delta antigen (HDAg) was first described by Rizzetto et aL. (1977). Hepatitis D virus (HDV), also known as the 'delta agent', is a satellite agent of hepatitis B virus (HBV). HDV does not synthezise its own coat; it is enveloped by hepatitis B surface antigen (HBsAg), which occurs as large (L), middle (M) and smaII or major (S) surface proteins, differing in the length of the amino-te...

When RNA polymerase II (RNAP II) is forced to stall, elongation complexes (ECs) are observed to leave the active pathway and enter a paused state. Initially, ECs equilibrate between active and paused conformations, but with stalls of a long duration, ECs backtrack and become sensitive to transcript cleavage, which is stimulated by the EC rescue factor stimulatory factor II (TFIIS/SII). In this ...

The incidence of hepatitis delta virus (HDV) infection in Northern Ireland (1970-1989) was tested by enzyme linked immunosorbent assay in 401 hepatitis B surface antigen (HBsAg) positive sera. Hepatitis delta antigen (HDAg) was tested in 388 patients and antibody to delta antigen (anti-HD) in 401 patients. Four patients (1.03%) were HDAg positive. Nine patients (2.24%) were positive for anti-HD...