OBJECTIVE C57Bl/6 mice develop obesity and mild hyperglycemia when fed a high-fat diet (HFD). Although diet-induced obesity (DIO) is a widely studied model of type 2 diabetes, little is known about beta-cell failure in these mice. RESEARCH DESIGN AND METHODS DIO mice were separated in two groups according to body weight gain: low- and high-HFD responders (LDR and HDR). We examined whether mil...

High-dynamic range (HDR) imaging is expected, together with ultrahigh definition and high-frame rate video, to become a technology that may change photo, TV, and film industries. Many cameras and displays capable of capturing and rendering both HDR images and video are already available in the market. The popularity and full-public adoption of HDR content is, however, hindered by the lack of st...

OBJECTIVE To compare survival and toxicity of three different treatments for stage IIIB cervix cancer: low-dose-rate (LDR), high-dose-rate (HDR) brachytherapy and association of HDR and chemotherapy. METHODS Between 1985 and 2005, 230 patients with FIGO stage IIIB squamous cell carcinoma of the uterine cervix received 4-field pelvic teletherapy at doses between 40 and 50.4 Gy, with a differen...

INTRODUCTION Ability to interpret facial expression is crucial for non-verbal communication among humans, and could be affected by changes in cerebral circulation during exposure to microgravity or its simulation. METHODS There were 16 subjects (8 men and 8 women) who were exposed to 24 h of -6 degrees head-down rest (HDR). Transcranial Doppler ultrasonography was used to monitor mean blood f...

Genome editing in induced pluripotent stem cells is currently hampered by the laborious and expensive nature of identifying homology-directed repair (HDR)-modified cells. We present an approach where isolation of cells bearing a selectable, HDR-mediated editing event at one locus enriches for HDR-mediated edits at additional loci. This strategy, called co-targeting with selection, improves the ...

One of the most successful methods for modern high quality HDR-video capture is to use camera setups with multiple sensors imaging the scene through a common optical system [1, 2, 3, 4]. However, such systems pose several challenges for HDR reconstruction algorithms. Previous reconstruction techniques have considered debayering, denoising, resampling (alignment) and exposure fusion as separate ...

Tone mapping or range reduction is often used in High Dynamic Range (HDR) visual signal compression to take advantage of the existing image/video coding architectures. Thus, it is important to study the impact of tone mapping on the visual quality of decompressed HDR visual signals. To our knowledge, most of the existing studies focus only on the quality loss in the resultant low dynamic range ...

A high dynamic range (HDR) imaging system, KIM05, has been developed to overcome the limitations of dynamic range of a typical digital image reproduction system. The first stage is an HDR image-assembling algorithm, which constructs an HDR image from a sequence of multiple image exposures of a scene. The second stage utilises a new file format to store the HDR image in three primaries of 16-bit...

Homology-directed repair (HDR) is essential to limit mutagenesis, chromosomal instability (CIN) and tumorigenesis. We have characterized the consequences of HDR deficiency on anaphase, using markers for incomplete chromosome separation: DAPI-bridges and Ultra-fine bridges (UFBs). We show that multiple HDR factors (Rad51, Brca2 and Brca1) are critical for complete chromosome separation during an...

Tone mapping of high dynamic range (HDR) images for realistic display is a commonly studied. However, scientific visualization of HDR image for analysis of scene luminance has much less attention. In this paper, we have presented and implemented a simple approach for the reproduction and visualization of the color information in HDR images. We attempt several simple color visualizing functions,...