Tumor-associated fibroblasts (CAFs) are a significant component of the tumor microenvironment (TME) head and neck squamous cell carcinoma (HNSCC) may stimulate their progression, although exact mechanisms not well understood. This work aimed to establish biologically relevant HNSCC model as basis for further investigations.

accumulating evidence suggests that self-renewal and differentiation capabilities reside only in a subpopulation of tumor cells, termed cancer stem cells (cscs), whereas the remaining tumor cell population lacks the ability to initiate tumor development or support continued tumor growth. in head and neck squamous cell carcinoma (hnscc), as with other malignancies, cscs have been increasingly sh...

introduction: nasopharyngeal carcinoma is one of the most common malignancies in the head and neck region and radiotherapy is its treatment of choice. in spite of the fact that it is widely used, due to the presence of many sensitive organs or tissues in this region, patients may suffer from a wide range of side effects. one such sensitive tissue is the spinal cord. if the absorbed dose to spin...

Head and neck cancer is the 5th most common cancer in the world with half a million new cases reported globally every year, 44,600 within the United States. Up to 40% of head and neck cancer patients will eventually die because of it. With half of patients having an advanced stage of disease upon initial diagnosis. Squamous cell carcinoma contributes to 95% of head and neck cancers. Squamous ce...

the optimal fractionation schedule for radiotherapy of head and neck cancer has been controversial. the objective of this randomized trial was to test the efficacy of hyperfractionation vs. standard fractionation. patients with squamous cell carcinoma of head and neck organs were randomly assigned to receive radiotherapy delivered with a) standard fractionation at 2 gy/fraction/day, 5 days/week...

squamous cell carcinoma (scc) is the most common malignancy of the oral cavity. this study aims to evaluate different treatment procedures including neo-adjuvant, concurrent and adjuvant therapy in treating squamous cell carcinoma of the head and neck by a meta-analysis.the authors searched all electronic databases (medline, embase and cochrane) for all the articles published from 1970 to janua...

Lymphoepithelial carcinoma (LEC) of the tongue is a rare subtype squamous cell carcinoma. Histologically, it an undifferentiated with rich lymphocyte and plasma infiltration. The most common location for LEC in head neck salivary glands, oral cavity extremely rare. second case report lateral presented. In addition, review literature was performed, relationship between Epstein–Barr virus infecti...

BACKGROUND The applicability of the melanoma antigen gene (MAGE) to the molecular diagnosis of cancer, by detecting MAGE mRNA in the sputa of head and neck cancer patients, was investigated. MATERIALS AND METHODS Nested reverse transcription-polymerase chain reaction (RT-PCR) with the MAGE common primers designed to detect MAGE A1-6 genes was conducted with sputa of 17 head and neck squamous ...

PURPOSE Head and neck squamous cell carcinomas have been reported to overexpress hypoxia-inducible factor (HIF)-1alpha, a transcription factor that promotes expression of angiogenesis factors and resistance to programmed and therapy-induced cell death. 2-Methoxyestradiol (2ME2) is a natural compound with HIF-1alpha inhibitory activity that is currently being evaluated in phase 1 and 2 clinical ...