Kinesin walks processively on microtubules in an asymmetric hand-over-hand manner with each step spanning 16 nm. We used molecular simulations to determine the fraction of a single step due to conformational changes in the neck linker, and that due to diffusion of the tethered head. Stepping is determined largely by two energy scales, one favoring neck-linker docking and the other, ε(h)(MT-TH),...

human immunodeficiency virus infection / acquired immunodeficiency syndrome (hiv/aids) is a disease pertained to the human immune system. given its crucial role in viral replication, hiv-1 protease (hiv-1 pr) is a prime therapeutic target in aids therapy. in this regard, the dynamic aspects of ligand-enzyme interactions may indicate an important role of conformational variability in hiv-1 pr in...

Electromagnetic docking technology can realize the flexible and safe separation of spacecraft, presents broad application prospects. However, an electromagnetic force with nonlinearity uncertainty properties increases difficulties control. In this work, magnetic dipole far-field model a single coil has been established by simplifying device. Afterward, torque models were obtained during space d...

This paper presents stress and strain analysis of outer shaft shoulder (OSS) and inner shaft shoulder (ISS) of a new paddy harvesting head (PHH) using finite element method (FEM). Snapping grain unit is a part of this head, with OSS and ISS as its members. The analysis was performed using the ABAQUS software with Dynamics Explicit Solution Method. Eight-node block and four-node tetrahedral elem...

The high incidence rate of concussions in football provides a unique opportunity to collect biomechanical data to characterize mild traumatic brain injury. The goal of this study was to validate a six degree of freedom (6DOF) measurement device with 12 single-axis accelerometers that uses a novel algorithm to compute linear and angular head accelerations for each axis of the head. The 6DOF devi...

{ This paper presents a sensor based docking strategy for a non holonomic mobile platform used to support material transportation operations in industrial like environments. A low cost in-frared sensor system was designed and implemented, aiming at locating the mobile platform relative to the docking station where passive reeectors are installed. With this information, trajectories are generate...

PURPOSE We validate a video-based method of head posture measurement. METHODS The Cambridge Face Tracker uses neural networks (constrained local neural fields) to recognize facial features in video. The relative position of these facial features is used to calculate head posture. First, we assess the accuracy of this approach against videos in three research databases where each frame is tagg...