BACKGROUND Maternal folic acid supplementation has been associated with a reduced risk for neural tube defects and may be associated with a reduced risk for congenital heart defects and other birth defects. Individuals with Down syndrome are at high risk for congenital heart defects and have been shown to have abnormal folate metabolism. METHODS As part of the population-based case-control Na...

Heart malformations are common congenital defects in humans. Many congenital heart defects involve anomalies in cardiac septation or valve development, and understanding the developmental mechanisms that underlie the formation of cardiac septal and valvular tissues thus has important implications for the diagnosis, prevention and treatment of congenital heart disease. The development of heart s...

Copyright © 2017 Heart and Health Foundation of Turkey (TÜSAV). Published by Medikal Akademi. This article is licensed by Medikal Akademi and TÜSAV under the terms of Creative Commons Attribution License. Eyileten Z., Uysalel A. Isolated ventricular septal defect in infants EJCM 2017; 05 (2): 27-33. Doi: 10.15511/ejcm.17.00227. Ventricular septal defect is a hole in the interventricular septum ...

The aim of the present study was to determine if patients with both pulmonary arterial hypertension (PAH), due to pulmonary vascular obstructive disease, and congenital heart defects (CHD), have mutations in the gene encoding bone morphogenetic protein receptor (BMPR)-2. The BMPR2 gene was screened in two cohorts: 40 adults and 66 children with PAH/CHD. CHDs were patent ductus arteriosus, atria...

BACKGROUND We assessed the global and regional ventricular septal functions using conventional echocardiography and two-dimensional speckle tracking imaging in children with postoperative multiple ventricular septal defects. METHODS Thirty-six children were studied: 16 with postoperative multiple ventricular septal defects and 20 normal control subjects. In children with multiple ventricular ...

Objective: The present article was motivated by the frustrating experiences with four patients who underwent surgical treatment of ostium secundum atrial septal defect (ASD-II) and who died in extremely dramatic circumstances. Method: This is a retrospective study based on clinical data. The bibliographical research included: paradoxical thromboembolism (cerebral, pulmonary or mesenteric), cent...

A growing list of transcatheter interventions is now available for treating patients with congenital and acquired heart disease. Among these procedures are creation of interatrial defects by balloon and blade septostomy , , balloon dilation of stenotic vessels and valves, and closure of unwanted intracardiac and extracardiac defects and vessels. This chapter focuses on several interventions: ba...