The heat shock proteins (hsps) are expressed in normal cells but their expression is enhanced by a number of different stresses including heat and ischaemia. They play important roles in chaperoning the folding of other proteins and in protein degradation. In the heart and the brain, a number of studies have shown that prior induction of the hsps by a mild stress has a protective effect against...

The 70-kDa heat shock proteins (HSP70s) are well-studied and characterized heat shock proteins (HSPs). They constitute essential components of a quality control system of protein synthesis, and function as molecular chaperones to prevent proteins from misfolding and aggregating during both de novo synthesis and under conditions of stress. Moreover, it is now well established that HSP70s play im...

Heat illness spans a broad spectrum of disease, with outcomes ranging from benign rash to fatal heat stroke. Heat illness is broadly divided into 2 types: classic and exertional. Both types occur as a result of exposure to elevated temperature with inadequate thermoregulation; however, classic illness occurs without preceding physical activity. Treatment consists of rapid cooling, fluid replace...

One of the main advantages of gene therapy over traditional therapy is the potential to target the expression of therapeutic genes in desired cells or tissues. To achieve targeted gene expression, we experimented with a new approach based on the long-established phenomenon of the heat shock response. By using the green fluorescence protein as a reporter gene, it was demonstrated that expression...

Physical therapy consists of fixation, thermotherapy, traction, and physical training. The symptomatic therapy is effective for some low back pain, including pain due to metastasis by malignant tumors. Fixation with a corset or wide canvas band reduces muscle pain in the low back region as curative therapy, but reduces the pain caused by tumors or inflammation as symptomatic therapy. Thermother...

STUDY DESIGN Cochrane systematic review. OBJECTIVE To assess the effects of superficial heat and cold therapy for low back pain in adults. SUMMARY OF BACKGROUND DATA Heat and cold are commonly used in the treatment of low back pain. METHODS We searched electronic databases from inception to October 2005. Two authors independently assessed inclusion, methodologic quality, and extracted dat...

today laser has a lot of usage in medicine and dentistry. in the field of dentistry, laser is used in soft tissue surgery, sterilization of canals (in root canal therapy) and in restorative dentistry laser is used for cavity preparation, caries removal, sealing the grooves (in preventive dentistry), etching enamel and dentin, composite polymerization and removal of tooth sensitivity. the use of...

An investigation designed to assess and compare the effects of therapeutic forms of heat and cold on the pain threshold of the normal shoulder is described. Heat and cold were both found to raise the normal pain threshold significantly, the maximum effect occurring immediately following treatment. Ice therapy was more effective than heat, but following both forms of treatment the effect rapidly...

The heat shock response first attracted the attention of molecular biologists because it offered an attractive experimental system for studying a small set of coordinately controlled genes. Further study showed that the heat shock response was actually an important homeostatic mechanism, enabling the cell to survive a variety of environmental stresses. The fundamental nature of this mechanism i...

In recent years there have been numerous randomized and nonrandomized studies conducted to assess the efficacy of hyperthermia combined with either radiation therapy or chemotherapy, especially in the treatment of superficially seated malignant tumors. The major impact of hyperthermia is currently on locoregional control of tumor. Heat may be directly cytotoxic to tumor cells or inhibit repair ...