The title compound, (5R,9R,13S,14S,17R)-14-hydroxy-3-methoxy-17-methyl-4,5-epoxymorphinan-6-one N-oxide, C(18)H(21)NO(5), has been prepared in a diastereomerically pure form by the reaction of oxycodone with 3-chloroperbenzoic acid and subsequent crystallization of the product from chloroform. The crystal packing shows that the molecule exhibits intramolecular O-H···O [D···A = 2.482 (2) Å] hydr...

Background: During the initial phase of an infection, there is an upregulation of inducible nitric oxide synthase in the macrophages for the production of nitric oxide. This is followed by the recruitment of polymorphonuclear leukocytes (neutrophils) which release arginase. Arginase competes with inducible nitric oxide synthase for a common substrate L-arginine. Objective: To investigate whethe...

In the title compound, C(13)H(10)ClNO, the central C-N bond has considerable double-bond character and the N-O bond indicates a formal negative charge on the O atom. The mol-ecule is stabilized by an intra-molecular C-H⋯O hydrogen bond. The geometry about the C=N bond is Z [C-C-N-O torsion angle = -4.2 (3)°] and the phenyl and benzene rings are trans-oriented around the C=N bond. The phenyl and...