EDITORIAL article Front. Oncol., 17 August 2023Sec. Hematologic Malignancies Volume 13 - 2023 | https://doi.org/10.3389/fonc.2023.1273598

PURPOSE The purpose of this study was to define the hematologic response to total splenectomy (TS) or partial splenectomy (PS) in children with hereditary spherocytosis (HS) or sickle cell disease (SCD). METHODS The Splenectomy in Congenital Hemolytic Anemia (SICHA) consortium registry collected hematologic outcomes of children with CHA undergoing TS or PS to 1 year after surgery. Using rando...

BACKGROUND Extracorporeal life support (ECLS) in patients with hematologic malignancies is considered to have a poor prognosis. However, to date, there is only one case series reported in the literature. In this study, we compared the in-hospital survival of ECLS in patients with and without hematologic malignancies. METHODS We reviewed a total of 66 patients who underwent ECLS for treatment ...

Anterior cervical diskectomy and fusion is a common spinal procedure. Over time, complications and hospital stay have decreased. However, to the authors' knowledge, no study has examined the necessity of routine postoperative hematologic laboratory studies for patients undergoing this procedure.From January 2005 through July 2010, four hundred thirty-four consecutive patients with cervical radi...

EDITORIAL article Front. Oncol., 17 August 2021Sec. Hematologic Malignancies Volume 11 - 2021 | https://doi.org/10.3389/fonc.2021.744009

abstract background brucella mellitensis, the most invasive strain of brucella, is the predominant strain of genus brucella in iran. it causes variety of hematological abnormalities some of which are frequent and causes difficulties in diagnosis. objective to find hematological abnormalities of brucellosis in hospitalized patients in an endemic area. materials and methods a retrospective review...

BACKGROUND The association between primary germ cell tumors of the mediastinum (the space between the lung pleura that contains the heart and other chest viscera) and hematologic malignancies has been described by retrospective analysis of patients treated at individual clinical centers. To better characterize the risk of hematologic disorders in patients with extragonadal germ cell tumors and ...

Immunotherapy with genetically engineered T-cells that express the chimeric antigen receptor (CAR) has raised hopes for the treatment of pediatric malignancies. Although CAR T-cell development is on a fast-moving pace and evolution, the context of exploring novel targetable antigens has been neglected. In this review study, we analyze the prominent hematologic antigens targeted by engineered T-...

The presence of terminal deoxynucleotidyl transferase (TdT) has been determined in neoplastic cells from 50 patients with non-hematologic tumors as well as neoplastic cells from 85 patients with hematologic malignancies. The results indicate that TdT is not present in cells from non-hematologic tumors, Hodgkin's lymphoma, B cell lymphoproliferative disorders, peripheral T cell neoplasms, reacti...