Histocompatibility in transplantation is governed by the products of the human leucocyte antigen (HLA) genes encoded within the major histocompatibility complex (MHC) on chromosome 6p21. HLA antigens define tissue type and are inherited en bloc in classical Mendelian fashion. Genotypically identical siblings inherit the same paternal and maternal chromosome 6. Haploidentical relatives share one...

introduction: monitoring the engraftment of donor cell after allogeneic blood stem cell transplantation is important for the early diagnosis of graft failure or relapse of disease. so analysis of donor chimerism has become a routine method for documentation of engraftment after allogeneic stem cell transplantation. in humans, the amelogenin gene is present on both the x and the y chromosomes. h...

background: burkitt lymphoma is a common subtype of non-hodgkin lymphoma in children. it has a rapid and aggressive clinical course with frequent involvement of bone marrow and central nervous system. systemic chemotherapy is the mainstay of the treatment for this malignancy in children. in this systematic review, we discuss autologous and allogeneic hematopoietic stem cell transplantation (hsc...

background: stem cell therapy is a new treatment option for different diseases. the aim of this systematic review is assessing the articles that focus on sct in iran and evaluate the amount of their success, failure and complication. methods: systematic search was conducted for finding english and persian papers (controlled trials and cohort studies with follow up) published before march 2015. ...

the increased risk of hemolytic reactions and erythrocyte recovery delay in abo incompatible hematopoietic stem cell transplantation (hsct) is well established. effects of abo incompatibility on transplantation outcomes is evaluated in this study. we prospectively followed 501 patients undergoing allogeneic stem cell transplantation according to abo compatibility groups of minor, major and bidi...

introduction: allogeneic hematopoietic cell transplantation (hsct) is the only therapeutic modality capable of correcting the hematologic manifestations of fanconi anemia (fa). the development  of well  tolerated,  immunosuppressive  conditioning  regimens  for fa patients  undergoing hsct has proven to be a rather challenging task for hematologists. methods: we analyzed the outcome of 30 fa pa...

conclusions in iran, hsct has been successfully adapted in routine clinical care. recently, new methods such as double cord blood and haploidentical transplantation have been used to treat many life-threatening diseases. results about 78.2% of the patients (2530 of 3237) remained alive between one to 211 months after stem cell transplantation. nearly, 21.8% (707) of our patients died after stem...

Stem cell therapy is promising for treatment of degenerative diseases. In Vietnam, stem cell applications have been performed since the 1990s. In addition to hematopoietic stem cell transplantation for malignant hematologic diseases and disorders, mesenchymal stem cells have also been clinically approved for treatment of diseases such as knee osteoarthritis, chronic obstructive pulmonary diseas...

hydroxymethylglutaryl co-enzyme a reductase inhibitors, also known as statins, are a class of anti-hyperlipidemic agents. these drugs have been employed vastly to reduce the morbidity and mortality of cardiovascular disorders. soon after their introduction, benefits other than their primary actions were discovered. along with these pleiotropic properties, a series of mainly favorable effects ha...