Onychomycosis (OM) is a common fungal infection of the toenails and/or fingernails that is highly prevalent in the general population and also responsible for significant morbidity. OM is caused by dermatophytes, nondermatophytic molds, or yeast. Today systemic antifungal agents are considered as the gold standard for all types of OM. Here we report a case of aplastic anemia associated with ora...

Background: Incidences of pediatric malignancies are increasing. In management various childhood like hematological, bone and soft tissue tumors radiotherapy plays a crucial role. RT treatment planning delivery poses challenge to clinicians. Hence with this study we wanted know the practices in our institution. Materials Methods: This was retrospective analyzing case records charts all who rece...

INTRODUCTION Valproic acid is a commonly used anti-epileptic drug. Hematological toxicities are among the occasionally observed adverse effects of this medication. CASE PRESENTATION We present the case of a 13-year-old Caucasian boy who demonstrated mild anemia 12 months after the introduction of valproic acid therapy. A bone marrow biopsy revealed maturation arrest of proerythroblasts. CON...

Hematopoietic stem cell transplantation (HSCT) has a half-century history. It is currently an indispensable treatment for not only incurable blood diseases such as aplastic anemia and severe hemolytic anemia, but also malignant hematological diseases such as leukemia and lymphoma. Although allergenic HSCT is also used to treat hereditary diseases, its indica‐ tions are restricted because of cri...

PURPOSE Essential thrombocythemia, polycythemia vera, and myelofibrosis are rare chronic hematological malignancies known as myeloproliferative neoplasms (MPNs) and are characterized by deregulated myeloid lineage cell production, splenomegaly, and heterogeneous symptom profiles. MPN patients suffer from a significant symptom burden (eg, fatigue, depressive symptoms, early satiety) and an impai...

Introduction: Over the last decades, a revolution has occurred in oncology with development of immune checkpoint inhibitors (ICIs). Following tremendous successes solid tumors, interest risen to explore these also hematologic malignancies, especially lymphomas. Biomarkers for ICIs response and resistance include PD-L1 expression other environmental factors, among which gut microbiome (GM) is ga...

Background: Arsenic toxicity is a major global health problem and exposure via contaminated drinking water has been associated with hematological and other systemic disorders. The present investigation has been conducted in adult male rats to evaluate the protective ability of α-lipoic acid (ALA) against such hematological disorders.Methods: Twenty-four adult male Wister rats (b.wt.130±10g) wer...

Introduction and aim. High grade glioma is the most aggressive form of primary brain tumour with a median survival one year. Maximal safe resection followed by temozolamide-based concurrent chemoradiation adjuvant chemotherapy standard care. To assess compliance temozolamide in patients high-grade who underwent Material methods. 30 high diagnosed treated our Oncology department during period Ma...

PURPOSE There is no established standard second-line chemotherapy for patients with advanced or metastatic urothelial carcinoma (UC) who failed gemcitabine and cisplatin (GC) chemotherapy. This study was conducted in order to investigate the efficacy and toxicity of modified methotrexate, vinblastine, doxorubicin, and cisplatin (MVAC) in patients with metastatic UC previously treated with GC. ...

BACKGROUND The aim of this study was to use pharmacokinetic analysis to investigate the efficacy and toxicity of combined chemotherapy with carboplatin (CBDCA) and etoposide (ETP) in small-cell lung cancer (SCLC) patients with chronic renal failure undergoing hemodialysis (HD). PATIENTS AND METHODS Three SCLC patients with chronic renal failure undergoing HD were treated with CBDCA (300 mg/m(...