BACKGROUND Familial hemiplegic migraine is a rare autosomal dominant subtype of migraine with aura that in half of the families is caused by mutations in the CACNA1A gene on chromosome 19p13. In sporadic hemiplegic migraine (SHM), that is, hemiplegic migraine without affected family members, the contribution of the CACNA1A gene is unknown. OBJECTIVE To investigate the involvement of the CACNA...

OBJECTIVE To study the clinical spectrum of CACNA1A S218L mutation carriers with special attention to "early seizures and cerebral oedema after trivial head trauma (ESCEATHT)", a combination of symptoms which resembles the "juvenile head trauma syndrome". PATIENTS AND METHODS In two patients with ESCEATHT all exons of CACNA1A were sequenced. Both patients also had hemiplegic migraine and atax...

Recent advances in genetics have shown the importance of the genetic component on migraine. Studies on twins also point out to the importance of genetic migraine. On the other hand, epidemiological data identified environmental factors that are important in the genesis of migraine. Studies on familial hemiplegic migraine with or without aura will certainly bring new information and help underst...

..................................................................................................................... 9 REVIEW OF THE LITERATURE .............................................................................. 10 1. CLINICAL CHARACTERISTICS OF MIGRAINE AND EPISODIC ATAXIA TYPE 2 ........................... 10 1.1. Migraine with and without aura .......................................

Migraine is a common, disabling, and undertreated episodic brain disorder that is more common in women than in men. Unbiased genome-wide association studies have identified 13 migraine-associated variants pointing at genes that cluster in pathways for glutamatergic neurotransmission, synaptic function, pain sensing, metalloproteinases, and the vasculature. The individual pathogenetic contributi...

A seven-year-old boy with migraine and a family history of hemiplegic migraine is described who, during an exacerbation, developed dysphasia and right hemiparesis. A CT scan showed a hypodense left cerebral lesion. Angiography revealed occlusion of the left middle cerebral artery at its origin. This represents the youngest case of stroke with migraine and, to our knowledge, is the first case re...

We report the first Korean patient with familial hemiplegic migraine type 1, with clinical and multimodal imaging findings. A 43-yr-old man was admitted for right hemianopia and aphasia, followed by coma. MRI showed only cerebellar atrophy. CT angiography showed mild vasodilation of intracranial blood vessels and increased vascularity in the left hemisphere and perfusion-weighted imaging showed...

BACKGROUND On trigeminal ganglion neurons, pain-sensing P2X3 receptors are constitutively inhibited by brain natriuretic peptide via its natriuretic peptide receptor-A. This inhibition is associated with increased P2X3 serine phosphorylation and receptor redistribution to non-lipid raft membrane compartments. The natriuretic peptide receptor-A antagonist anantin reverses these effects. We studi...

The wide variety of hemiplegic sling designs, the lack of a uniform approach to sling selection, and the paucity of research data in this area have tended to make prescribing a sling a subjective process. Based on clinical experience and a comprehensive literature review, the authors propose a checklist for examining hemiplegic slings. The Checklist, which includes 19 desirable and 4 undesirabl...

Neurologic symptoms are a prominent and often disturbing component of the migraine syndrome in many patients. Collectively termed "aura," migraine-related neurologic symptoms include visual, sensory, language, and motor disturbance. They occur in about one quarter of migraine patients, are classically transient, and are thought to occur as the result of cortical phenomena. Recently, motor sympt...