Asymmetric bi-soft segment poly(ester urethane urea) (PEUU) membranes containing polycaprolactone (PCL) as a second soft segment are synthesized with PCL-diol ranging from 0% to 15% (w/w). Bulk and surface characteristics of the PEUU membranes were investigated by scanning electron microscopy (SEM), static water contact angles, and surface streaming potentials and were correlated to hemocompati...

Magnesium (Mg) and its alloys have attracted considerable attention owing to their excellent biodegradable properties biocompatibility. Novel Mg–Sn–Ge ternary Mg were developed as potential materials for orthopedic applications because of alloying elements naturally present in humans. The feasibility these was investigated terms mechanical properties, degradation, cytocompatibility, hemocompati...

Continuous improvement of both perfusion techniques and perfusion equipment has led to decreased morbidity after neonatal and pediatric cardiopulmonary bypass. Small pediatric circuits have been developed to decrease priming volume and foreign surface area. However, it is not clear if our existing technology allows for further miniaturization of the circuit without jeopardizing safety and hemoc...

Implantable devices are highly susceptible to infection and are therefore a major risk in surgery. The present work presents a novel strategy to prevent the formation of a biofilm on polytetrafluoroethylene (PTFE) grafts. PTFE grafts were coated with gentamicin and teicoplanin incorporated into different lipid-like carriers under aseptic conditions in a dipping process. Poly-d,l-lactic acid, to...

Although endovascular stenting has been used as an interventional therapy to treat cardio- and cerebro-vascular diseases, it is associated with recurrent vascular diseases following stent thrombosis and in-stent restenosis. In this study, a metallic stent was coated with dopamine-conjugated hyaluronic acid with different ratios of catechol group to improve hemocompatibility and re-endothelializ...

Although the behavior of nanoscopic delivery systems in blood is an important parameter when contemplating their intravenous injection, this aspect is often poorly investigated when advancing from in vitro to in vivo experiments. In this paper, the behavior of siRNA loaded dextran nanogels in human plasma and blood is examined using fluorescence fluctuation spectroscopy, platelet aggregometry, ...