A PREVIOUS report on the mechanism of action of chlorothiazidel was based on observations on hemodynamic functions. Studies of specific renal functions were done concurrently in some of the patients and in others that were treated identically, except for the omission of some of the hemodynamic observations. The results show that, in addition to its recognized saluretic and kaluretic properties,...

Many cell-free hemoglobin solutions designed as oxygen-carrying therapeutics produce a hypertensive effect in animals. The response is likely due to oxidation of nitric oxide by hemoglobin. Since the site of oxidation may lie outside the vascular compartment, we tested the hypothesis that polymerization of hemoglobin, rHb1.1, by glutaraldehyde would attenuate the hypertensive response. Two prod...

In functional magnetic resonance imaging (fMRI), modeling the complex link between neuronal activity and its hemodynamic response via the neurovascular coupling requires an elaborate and sensitive response model. Methods based on physiologic assumptions as well as direct, descriptive models have been proposed. The focus of this study is placed on such a direct approach that allows for a robust ...

The physiological limitations of the Fontan circulation have been extensively addressed in the literature. Many studies emphasized the importance of pulmonary vascular resistance in determining cardiac output (CO) but gave little attention to other cardiovascular properties that may play considerable roles as well. The present study was aimed to systemically investigate the effects of various c...

Hemodynamic responses are commonly used to map brain activity; however, their spatial limits have remained unclear because of the lack of a well-defined and malleable spatial stimulus. To examine the properties of neural activity and hemodynamic responses, multiunit activity, local field potential, cerebral blood volume (CBV)-sensitive optical imaging, and laser Doppler flowmetry were measured ...

introduction: cardiac dysfunctions have been well known in patients with major thalassemia. some studies have focused on differences in blood pressure and heart rate between these patients and normal population, while this view has not been proven in other studies. given the importance of hemodynamic factors in the health of these individuals, we intend to test the hypothesis as to whether or n...

background: etomidate and propofol are common anesthetic agents. previous studies say that etomidate can be used in patients with limited hemodynamic reserve and propofol can lead to more hemodynamic instabilities. th is study was performed to explore the cardiovascular response during the induction of anesthesia with etomidate or for comparison, propofol in elective orthopedic surgeries. mater...