OBJECTIVE To identify risk factors associated with higher rates of ocular complications in children with traumatic hyphema. METHODS Consecutive inpatient records from July 1990 through December 1997 were retrospectively reviewed for all children (aged < or = 18 years) who were admitted to the Wilmer Ophthalmological Institute, Baltimore, Md, within 48 hours of a closed-globe injury leading to...

Objective: Premarital hemoglobinopathy screening is one of the important procedures of hemoglobinopathy control programs. This is the first report about the prevalence of hemoglobinopathies in Kocaeli. Materials and Methods: The study covered screening from July 2005 to the end of December 2008. Under the auspices of the Ministry of Health and regional health authorities, blood samples of the c...

OBJECTIVE To study breastfeeding history (BF) and the anthropometric status of children with Sickle Cell Disease (SCD). METHODS A cross-sectional study of 357 children with SS and SC hemoglobinopathies aged between 2 and 6 years old receiving regular follow-up at a Newborn Screening Reference Service (NSRS) between November 2007 and January 2009. The outcome was anthropometric status and the ...

INTRODUCTION Thalassemia and iron deficiency may both result in hypochromic microcytic anemia. Hematological algorithms that differentiate the two are mainly established in adult selected diagnostic groups. We aimed at creating an algorithm applicable in the presence of children, hemoglobin variants, and iron deficiency. METHODS Our study material constituted blood samples referred during 1 y...

Sickle cell disease is a hemoglobinopathy that results in paroxysmal arteriolar occlusion and tissue infarction that can manifest in a plurality of tissues. Rarely, these infarcted crises manifest in the bony orbit. Orbital infarction usually presents with acute onset of periorbital tenderness, swelling, erythema, and pain. Soft tissue swelling can result in proptosis and attenuation of extraoc...

I have read with admiration the paper by Bahadır et al. entitled “HbD Los Angeles [beta 121(GH4) Glu→Gln] and Hb Beograd [beta 121(GH4) Glu→Val]: implications for their laboratory diagnosis and genetic origins” in the recent issue of the journal [1]. However, I was puzzled regarding the reasons for these studies of HbD Los Angeles, since the presence of this hemoglobinopathy trait even in homoz...

We attempted to measure the benefits of a communitywide hemoglobinopathy screening program by reviewing the numbers of newborns detected to have a hemoglobinopathy, the level of utilization of prenatal diagnostic services, and the number of hemoglobinopathies diagnosed prenatally. We measured the effect of our program on 14,051 infants born over a five year period and their families. Results: T...

BACKGROUND Newborn screening (NBS) for hemoglobinopathies facilitates early identification of affected individuals to ensure the prompt institution of comprehensive medical care for affected newborns in California. When linked to extensive follow-up and education, NBS has been shown to significantly reduce mortality in children with sickle cell disease. Due to changing immigration patterns from...

OBJECTIVE To describe and quantify the main changes seen on computed tomography of the chest in mildly symptomatic adult patients with sickle cell disease, as well as to evaluate the radiologist accuracy in determining the type of hemoglobinopathy. MATERIALS AND METHODS A prospective study involving 44 adult patients with sickle cell disease who underwent inspiration and expiration computed t...

The small mean corpuscular volume (MCV) of red blood cell is one of the indicators for thalassemia and hemoglobinopathy screening. As other screening methods, it may have some degrees of limitation. The retrospective study was performed among 104 patients who had various kinds of thalassemia or hemoglobinopathy despite having normal hemoglobin (Hb) concentration and normal mean corpuscular volu...