Introduction: A theoretical MR model has been proposed that separately quantifies dispersed (soluble, ferritin-like) and aggregated (insoluble, hemosiderin-like) iron by distinguishing their effects on R2 relaxation curves. Recently, this model has been validated in agarose phantoms using MnCl2 and iron oxide microspheres to mimic ferritin and hemosiderin iron, respectively. Here, we directly m...

Mild discolouration of the articular cartilage is known to gradually occur during aging. However, pathological tissue pigmentation is occasionally induced under several specific conditions. In the present case, we performed total knee replacement in a patient with recurrent haemarthrosis. However, during the operation, we observed severe black colouration of the knee articular cartilage, due to...

Deferiprone Superficial siderosis (SS) is a neurodegenerative condition caused by hemosiderin deposition on the surface of the brain, cranial nerves, and spinal cord. SS is an exceptionally rare condition characterized by a triad of hearing loss, ataxia, and myelopathy. The most common etiologies that lead to SS are trauma, previous surgical procedures, dural tears, and tumors of the central ne...

BACKGROUND AND PURPOSE Superficial siderosis is a neurodegenerative disease caused by toxic accumulation of hemosiderin on the surface of the brain and spinal cord for which there is no known effective treatment. METHODS Oral deferiprone, a lipid-soluble iron chelator with ability to cross the blood-brain barrier, at a dose of 30 mg/kg per day was tested for safety in an open pilot study in 1...

With transfusional iron overload, almost all the excess iron is sequestered intracellularly as rapidly mobilizable, dispersed, soluble ferritin iron, and as aggregated, insoluble hemosiderin iron for long-term storage. Established magnetic resonance imaging (MRI) indicators of tissue iron (R(2), R(2)*) are principally influenced by hemosiderin iron and change slowly, even with intensive iron ch...

BACKGROUND Intracranial hemorrhage in central nervous system lymphoma is extremely rare. T2*-weighted gradient-echo magnetic resonance imaging is of particularly use in detecting silent hemorrhage as hypointense signals due to the deposition of paramagnetic hemosiderin or mineralization. Multifocal hemosiderin depositions caused by chronic silent hemorrhage have not yet been identified in patie...

BACKGROUND The aim of this study is to explore the treatment and outcome of epileptogenic temporal lobe cavernous malformations (CMs). METHODS We analyzed retrospectively the profiles of 52 patients diagnosed as temporal lobe CMs associated with epilepsy. Among the 52 cases, 11 underwent a direct resection of CM along with the adjacent zone of hemosiderin rim without electrocorticogram (ECoG)...

In pernicious anemia and hemochromatosis an iron-containing pigment, hemosiderin, ordinarily derived from hemoglobin, is deposited in organs free from such pigment in most conditions that involve blood destruction. When sudden hemolysis takes place in a previously healthy human being, as after cutaneous burns or the action of a "blood poison," hemosiderin granules appear in the spleen, the red ...