gastrointestinal stromal tumors are mesenchymal neoplasms of the gastrointesti- nal tract that originate from all areas of the gastrointestinal tract. metastases to the liver, peritoneum, bones, lungs and soft tissues have been reported. we present the case of a 47- year-old woman with rectal gastrointestinal stromal tumor that underwent wide local excision. she was treated with imatinib for a ...

Ethanol metabolism causes oxidative stress and lipid peroxidation not only in liver but also in extra-hepatic tissues. Ethanol administration has been shown to cause oxidative degradation and depletion of hepatic mitochondrial DNA (mtDNA) in rodents, but its in vivo effects on the mtDNA of extra-hepatic tissues have not been assessed. We studied the effects of an acute intragastric ethanol admi...

Objective(s): Newer organo-metallic, specifically gold (III) complexes with multiple ligands are currently being formulated with primary focus of having increased anti-cancerous properties and decreased cytotoxicity. In this study, histological toxicity profile of a newly formulated anti-cancerous gold (III) compound [trans-(±)-1,2-(DACH)2Au]Cl3 Bis(trans-1,2-Diaminocyclohexane) was investigate...

Because hepatic cysteine dioxygenase (CDO) appears to play the major role in controlling cysteine catabolism in the intact rat, we characterized the effect of a lack of hepatic CDO on the regulation of cysteine and its metabolites at the whole body level. In mice with liver-specific deletion of CDO expression, hepatic and plasma cysteine levels increased. In addition, in mice with liver-specifi...

BACKGROUND Obesity has become a leading global health problem owing to its strong association with a high incidence of diseases. AIM To induce rat obesity using high fat diet (HFD) and to estimate oxidative stress markers in their liver, heart and kidney tissues in order to shed the light on the effect of obesity on these organs. MATERIALS AND METHODS Sixty white albino rats weighing 150-20...

OBJECTIVE Carbohydrate response element binding protein (ChREBP) is a transcription factor that responds to glucose and activates genes involved in the glycolytic and lipogenic pathways. Recent studies have linked adipose ChREBP to insulin sensitivity in mice. However, while ChREBP is most highly expressed in the liver, the effect of hepatic ChREBP on insulin sensitivity remains unknown. To cla...

a 3-month-old male german shepherd dog was referred with depression, vomition, hemorrhagic diarrhea, abdominal pain, anorexia and dehydration. the affected dog did not have any history of vaccination. despite treatment, the animal died within 2 days after the onset of clinical signs. gross examination of tissues showed hemorrhages (ecchymoses) in the mucosa of the digestive tract. the liver was...