conclusions genotype d was the main genotype detected in romanian patients with chronic hbv infection. genotype d presented both bcp and pc mutations more frequently. results we detected two hbv genotypes; a (8.1%) and d (60.5%), and a mixture of genotypes a and d (31.4%) (p < 0.001). basal core promoter (bcp) a1762t/g1764a and precore (pc) g1896a mutations were detected in these romanian patie...

conclusions expression of hmgb1 and c-iap2 proteins was associated with hcc development and progression, and the expression of hmgb1 and c-iap2 proteins in hcc were significantly associated with each other. additionally, these proteins may show promise as biomarkers to predict hcc progression. background hepatocellular carcinoma (hcc) is one of the most important health problems in china. objec...

liver lesion is a common condition, which often detect incidentally. a large proportion of liver masses can be diagnosed by progression in imaging modalities. although, definite diagnosis of liver mass's nature can be made by biopsy of lesion and histopathologic examination, but with imaging findings, we can approach to the diagnosis. in this study, we review many valuable articles and scientif...

conclusions the data from this cohort indicates that most of patients diagnosed with hcc present at late tumor and liver disease stages, when prognosis is usually dismal. regular cancer surveillance in cirrhotic patients might change the outcomes. further studies with results of treatment outcomes in this community are needed. background hepatocellular carcinoma (hcc) is one of the leading caus...

conclusions the established method has an acceptable performance in quantifying yb-1. in addition, serum yb-1 may aid in the diagnosis of hcc. results the developed method was linear to 150 μg/l of yb-1 with a minimum detection limit of 0.01 μg/l. the average recoveries were between 93.9% and 109.0%. the mean intra- and inter-assay coefficients of variation (cvs) were 4.0-4.8% and 8.2-10.2%, re...

conclusions cd5l might be a useful biomarker for early diagnosis of hcc in hcv cirrhotic patients. lrg and hp α2 isoforms could be potential markers for distinguishing viral hcc. our results also further support the presence of varying molecules involved in hepatocarcinogenesis in hbv when compared with hcv infection. patients and methods two-dimensional polyacrylamide gel electrophoresis combi...

conclusions hbv and hcv are important culprits of hcc in emro countries and the middle east and different nations need different strategies to tackle them accordingly. countries with high rates of hbv such as turkey should continue their hbv vaccination and also increase sanitation. nations with high hcv rates such as egypt should maintain their blood product monitoring in addition to increased...

conclusions our results suggest that h. parva and h. oculata may be promising therapeutic candidates for the treatment of hcc, following further confirmatory in vivo experiments and clinical trials. results our results showed that h. parva methanolic extracts (250, 500, and 1000 µg/ml) and h. oculata methanolic extracts (200, 400, and 800 µg/ml) increased reactive oxygen species (ros) formation...

Molecular analysis of primary liver malignancies has provided a refinement the pathological diagnosis this entity and identification an increasing number tumor subtypes hepatocellular proliferation, either malignant (hepatocellular carcinomas) or benign adenomas). Besides diagnosis, combined pathomolecular approach can also provide further insights into patient prognosis, help select patients w...

results patients who attained sustained virological response had a less risk (85%) for all-cause mortality and about 63% reduced risk of hepatocellular carcinoma incidence than those who did not achieve sustained virological response. based on deeply analysis, the stage of liver fibrosis was a risk factor at baseline for the incidence of hepatocellular carcinoma. conclusions sustained virologic...