skull metastasis from hepatocellular carcinoma, specially as the first presentation is very rare. we report a case with a history of head trauma in bam earthquake and craniotomy due to lytic tumor of the skull, presented with upper gastrointestinal symptoms which hepatocellular carcinoma with skull metastasis was revealed .the patient was infected with hepatitis b virus without cirrhosis.

background the fas receptor/ligand system including soluble forms is the most important apoptotic initiator in the liver. dysregulation of this pathway may contribute to abnormal cell proliferation and cell death and is regarded as one of the mechanisms preventing the immune system from rejecting the tumor cells. objectives to analyze the role of fas system fas/ fas ligand (fas/ fasl) in the mu...

background human telomerase reverse transcriptase (htert) has become an ideal target for development of anticancer therapy. small interfering rnas (sirnas) are very powerful reagents for gene silencing and show promise for cancer gene therapy. however, only a small number of sirnas have been demonstrated to be effective. for gene therapy targeting htert, it is essential to develop a robust syst...

conclusions the polymorphism and promoter methylation of rassf1a may be a significant factor in hcc, and can be an indicator for poor prognosis in patients with hcc. background the functional and prognostic significance of ras association domain family 1a gene (rassf1a) on hepatocellular carcinoma (hcc) has not been well characterized. objectives this study aimed to investigate the association ...

conclusions chronic hepatitis c-related liver diseases impose a substantial economic burden on patients, families and the society. the current study provides useful information on cost of treatment and work loss for different disease states, which can be further used in cost-effectiveness evaluations. results the total annual cost per patient for chronic hepatitis c, cirrhosis and hepatocellula...

discrimination of regenerative cirrhotic nodules of the liver (cn) from hepatocellular carcinoma (hcc) is sometimes difficult. we examined the utility of agnor staining in this context. fifteen cases of hcc and 25 cases of cn were stained by agnor method and the mean agnor number for one hundred nuclei in each case was determined. there was a significant difference between the mean agnor counts...

objectives and background: mutation directed inactivation of the tumor suppressor gene p53 have been found incountries with high frequency for hepatocellular carcinomas (hccs). our goal in the present study was screening of the p53 gene in tumor tissues from hcc affected individuals in southwest iran for putative mutations in exons 7 and 8 that are known as hot spot regions. materials & met...

liver lesion is a common condition, which often detect incidentally. a large proportion of liver masses can be diagnosed by progression in imaging modalities. although, definite diagnosis of liver mass's nature can be made by biopsy of lesion and histopathologic examination, but with imaging findings, we can approach to the diagnosis. in this study, we review many valuable articles and scientif...