Wilson's disease is an inborn error of copper metabolism that characterized by deficiency ceruloplasmin, the serum transport protein for copper. Copper collected in liver, and after hepatic binding sites are saturated, it released. Systemic then develops there abnormal accumulation brain, particularly putamen globus pallidus. Presenting this case a 32-year-old male patient who presented with pe...

The vertebral column from a known case of Wilson's disease (hepatolenticular degeneration) was examined by radiological, histological, histochemical and x-ray microanalytical techniques which demonstrated the presence of focal depositions of calcium pyrophosphate dihydrate (CPPD) in the intervertebral discs. These deposits were present in both the annulus fibrosus and the nucleus pulposus but i...

Wilson's disease (WD), also called hepatolenticular degeneration, is an autosomal recessive inheritance disorder of copper metabolism characterized by the multiple mutations in the ATP-ase 7B gene of chromosome 13q. About half of the WD patients have neurological or psychiatric symptoms. As WD is a kind of medicable or nearly curable neurodegenerative disease in the field of medicine, early con...

T1 relaxation time sufficient to produce pallidal T1 hyperintensity in hepatolenticular degeneration. [4] Manganese is also used as MR contrast due to the above properties but surprisingly SWI failed to show any blooming. Interestingly, calcification containing diamagnetic calcium is visualized in SWI and hence is used in the seizure MR imaging protocol.[5] The magnetic susceptibility of parama...

AIM Acquired hepatocerebral degeneration (AHD) is an exceptional type of hepatic encephalopathies (HE). It is characterized by neuropsychiatric and extrapyramidal symptomatology similar to that seen in hepatolenticular degeneration (Wilson's disease). In this paper, we report a case of AHD with unusual presenting features. METHODS A 28-year-old man with AHD was described and the literature wa...