Previously explored combination therapies mostly involved the use of bioactive molecules. It is believed that herbal compounds containing multiple plant products have synergistic hepatoprotective effects and could enhance the desired actions. To investigate the combination of ethanolic fruits extract of Solanum xanthocarpum (SX) and Juniperus communis (JC) against Paracetamol (PCM) and Azithrom...

Silymarin, a known extract, is used in the treatment of liver diseases with various origins, but its current administration form cannot target the liver because of its poor oral bioavailability. A new type of oral silymarin proliposome aimed at improving silymarin's poor bioavailability and hepatoprotective effects, is introduced in this work. Silymarin-loaded liquid proliposome were prepared u...

Different fraction obtained from the aerial parts of Juniperus phoenicea showed significant activity as hepatoprotective when investigated against carbon tetrachloride induced liver injury. The hepatoprotective activity was evaluated through the quantification of biochemical parameters and confirmed using histopathology study. Phytochemical investigation of the petroleum ether, chloroform and m...

Thespesia lampas (Cav.) Dalz & Gibs an important folk medicinal plant was evaluated for hepatoprotective and antioxidant activity against carbon tetrachloride (CCl4) induced hepatic damage in rats. In the present study, the T. lampas stems extracts at dose of 200 mg/kg body wt. were administered orally once daily for nine days and on seventh day after one hour of drug administration CCl4 (1ml/k...

Introduction: Acacia catechu is a deciduous, thorny tree which grows up to 12-15 meter in height. In Hindi is called as Khair and in kannada Kachu. It has been used as used for the treatment of inflammation, diarrhheoa, fever. Aims: to evaluate the hepatoprotective effect of ethanolic extract of acacia catechu in paracetemol induced liver damage in experimental animals, rats was studied. Method...

Butea monosperma (Lam.) (family: Fabaceae) popularly known as 'Palas' or 'fire of forest' has been used traditionally as a hepatoprotective agent. This study evaluated the hepatoprotective and antitumorigenic properties of the aqueous extract and butanol fractions of B. monosperma flowers in animal models. Dried flowers of B. monosperma were extracted with water and fractionated further using n...

background: hyperthyroidism is associated with liver oxidative stress causing liver dysfunction in many hyperthyroid patients. the hepatoprotective effect of satureja khuzestanica essential oil (skeo), as herbal origin antioxidant and anti-inflammatory agent on the hyperthyroidism induced hepatotoxicity and oxidative stress is investigated. methods: adult male sprague dawley rats were divided i...

BACKGROUND Fulminant hepatic failure (FHF) is clinical syndrome with very poor prognosis and high mortality there is urgent need for the development of safe and non-toxic hepatoprotective agents for the adequate management of hepatitis. Hepatoprotective effect of the Lepidium sativum ethanolic extract (LSEE) was assessed by D-galactosamine-induced/lipopolysaccharide (400 mg/kg and 30 μg/kg) liv...

Purpose: The effects of oral administration of ethyl acetate, ethanol and aqueous extracts of Adenema hyssopifolium G.Don (Gentianaceae) on carbon tetrachloride-induced liver disorders were investigated. Methods: Rats were individually treated daily with 300 and 600 mg/kg dose of either ethyl acetate, ethanol or aqueous extracts of A. hyssopifolium, respectively, following induction of liver da...

OBJECTIVE The stem bark of Mammea africana Sabine (Guttiferae), (M. africana) a common plant that has been traditionally used to treat various diseases and ailments was evaluated for hepatoprotective potentials against paracetamol-induced liver injury in rats. MATERIALS AND METHODS The hepatoprotective effect of the stem bark extract (30-90 mg/kg) was evaluated by the assay of liver function ...