The development of effective therapies inhibiting prostate cancer progression and metastasis may substantially impact prostate cancer mortality and potentially reduce the rates of invasive treatments by enhancing the safety of active surveillance strategies. Hepsin (HPN) is a cell surface serine protease amplified in a subset of human sarcomas (7.2%), as well as in ovarian (10%), lung adeno (5....

Background: Hepsin is known as a cell-surface serine protease expressed predominantly in the liver. Hepsin-deficient mice show resistance to high-fat diet-induced obesity, hyperlipidemia, and hyperglycemia. Up present, physiological function of hepsin has not been fully determined. may play significant specific roles diabetes. Objectives: This study aimed evaluate relationship between protein c...

HGF (hepatocyte growth factor) is a pleiotropic cytokine homologous to the serine protease zymogen plasminogen that requires canonical proteolytic cleavage to gain functional activity. The activating proteases are key components of its regulation, but controversy surrounds their identity. Using quantitative analysis we found no evidence for activation by uPA (urokinase plasminogen activator), d...

Although loss of epithelial integrity is a hallmark of advanced cancer, it remains poorly understood whether genetic alterations corrupting this integrity causally facilitate tumorigenesis. We show that conditional deletion of tumor suppressor gene Lkb1 (Par-4) in the mammary gland compromises epithelial integrity manifested by mislocalization of cell polarity markers, lateralization of tight j...

Tumours are capable of activating blood coagulation through the expression of procoagulant molecules such as tissue factor, cancer procoagulant and hepsin. Initiation of the clotting cascade results in the generation of the activated serine proteases factor VIIa, factor Xa and thrombin. These proteases act via protease-activated receptors and tissue factor to alter gene expression, thereby modu...

Adipose tissue is a crucial organ in energy metabolism and thermoregulation. phenotype controlled by various signaling mechanisms under pathophysiological conditions. Type II transmembrane serine proteases (TTSPs) are group of trypsin-like enzymes anchoring on the cell surface. These act diverse tissues to regulate physiological processes, such as food digestion, salt-water balance, iron metabo...

Cleavage of influenza virus hemagglutinin (HA) by host proteases is essential for infectivity. HA most A and B (IAV/IBV) viruses cleaved at a monobasic motif trypsin-like proteases. Previous studies have reported that transmembrane serine protease 2 (TMPRSS2) activation H7N9 H1N1pdm IAV in mice but H3N2 IBV independent TMPRSS2 carried out as-yet-undetermined protease(s). Here, to identify addit...