In recent years, a greater number of germinal mutations that predispose to the development tumors have been found. Understanding interactions between and breast cancer’s subtype is essential for opening new therapeutic preventive strategies. It well known what type cancer develops in hereditary syndrome context; however, prevalence HER2 positive with some deleted mutation genes predisposing can...

BACKGROUND There is limited effect of tyrosine kinase inhibitors or "naked" antibodies binding EGFR or HER2 for therapy of metastasized urinary bladder cancer and these methods are therefore not routinely used. Targeting radio-nuclides to the extracellular domain of the receptors is potentially a better possibility. METHODS EGFR- and HER2-expression was analyzed for primary tumors and corresp...

The human epidermal growth factor receptors (HER), also known as ERBB receptors, are a family of signal transduction proteins. There are 4 family members in humans—HER1, HER2, HER3, and HER4—each of which is composed of an extracellular (ligandbinding) domain, a transmembrane domain, and an intracellular tyrosine kinase, except for HER3, which lacks a tyrosine kinase domain (Figure 1). HER-fami...

The reliability of the rabbit monoclonal antibodies SP1, SP2, SP3, and 4B5 was immunohistochemically assessed on a range of 96 invasive breast and carcinomas and the results compared with those achieved with established antibody markers for estrogen receptors (6F11), progesterone receptors (PgR636), and HER2 (polyclonal A0485 and clone CB11), with HER2 status validated by fluorescence in situ h...

PURPOSE ZD1839 is a tyrosine kinase inhibitor of the epidermal growth factor receptor (EGFR) that has shown clinical activity against EGFR-expressing tumors. Our aim was to explore the effects of ZD1839 in breast cancer cell lines expressing different levels of EGFR and the closely related HER2 receptor. EXPERIMENTAL DESIGN We studied the growth-inhibitory effects of ZD1839 in a series of bre...

Herpes simplex virus (HSV) enters cells by means of four essential glycoproteins - gD, gH/gL, gB, activated in a cascade fashion by gD binding to one of its receptors, nectin1 and HVEM. We report that the engineering in gH of a heterologous ligand - a single-chain antibody (scFv) to the cancer-specific HER2 receptor - expands the HSV tropism to cells which express HER2 as the sole receptor. The...

herein, 1f2, an anti-her2 monoclonal antibody (mab), was covalently coupled to the surface of 5-fluorouracil (5-fu) loaded bovine serum albumin (bsa) nanoparticles. concerning two different crosslinkers for conjugation of 1f2, maleimide-poly (ethylene glycol)-succinimidyl carbonate (mal-peg5000-nhs) was selected due to its higher conjugation efficiency (23±4 %) obtained in comparison to n-succi...

Background: Human epidermal growth factor 2 (HER2) is known to be an important prognostic in breast cancer. Numerous studies have shown HER2+ cancers reduced overall survival and recovery time, as well the efficacy of anti-HER2 therapies along with chemotherapy improving disease outcomes. For this reason, it recommended that all patients cancer should evaluated for HER2 status. This study aimed...

BACKGROUND Hormone receptors, including the estrogen receptor and progesterone receptor, human epidermal growth factor receptor 2 (HER2), and other biomarkers like Ki67, epidermal growth factor receptor (EGFR, also known as HER1), the androgen receptor, and p53, are key molecules in breast cancer. This study evaluated the relationship between HER2 and hormone receptors and explored the addition...

NK cells detect tumors through activating surface receptors, which bind self-antigens that are frequently expressed upon malignant transformation. To increase the recognition of tumor cells, the extracellular domains of ligands of the activating NK cell receptors NKp30, NKp80 and DNAM-1 (i.e. B7-H6, AICL and PVR, respectively) were fused to a single-chain fragment variable (scFv) targeting the ...