Systemic administration of recombinant thrombomodulin (TM) confers radiation protection partly by accelerating hematopoietic recovery. The uniquely potent radioprotector gamma tocotrienol (GT3), in addition to being a strong antioxidant, inhibits the enzyme hydroxy-methyl-glutaryl-coenzyme A reductase (HMGCR) and thereby likely modulates the expression of TM. We hypothesized that the mechanism ...

Radiation therapy is one of the most important strategies in cancer treatment with irreplaceable advantages. However, it should not be overlooked that the immune damage caused by radiation therapy, which means that radiation therapy could lead to the immune function lessening and immune organ damage (Hu et al., 1988; Uh et al., 1994). The immune system damage could further weaken the immune fun...

Due to the increased use of ionizing radiation in various aspects of human life especially in areas pertaining to radiotherapy of cancer, food preservation, agriculture, industry and power generation, there is a need to develop an effective and non-toxic radioprotector. The currently available ones have many drawbacks including high cost, side effects and toxicity. Several novel approaches are ...

Ionizing radiation causes severe damage to human body, and normal tissue toxicity in cancer radiotherapy also limits its further application. It is urgently required to develop safe and effective radioprotector. Our previous study has shown that toll like receptor 4 (TLR4) was dispensable for basal radiation resistance. However, severe toxicity of its traditional agonist lipopolysaccharide limi...

control group (radiation only). A & B: CT scans with radiation treatment planning superimposed. Area in red received full radiation dose (3x11Gy). All animals received radiation in same location. C & D: CT scans at 8 weeks post radiation. While lung in C has homogeneous tissue density, the lung in D shows an area of hypodensity that correlates with the irradiated area (oval and arrow). E & F: c...

The development of radiation countermeasures for acute radiation syndrome (ARS) has been underway for the past six decades, leading to the identification of multiple classes of radiation countermeasures. However, to date, only two growth factors (Neupogen and Neulasta) have been approved by the United States Food and Drug Administration (US FDA) for the mitigation of hematopoietic acute radiati...

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BACKGROUND The use of complementary and alternative medicine including herbal medicine is increasing in many countries including Ghana. However, there is paucity of research on the perspectives of patrons of herbal medicine regarding the facilitators and barriers of herbal medicine use. This study sought to investigate the facilitators and barriers of herbal medicine among Ghanaian adults who u...