acyclovir (9-[2-hydroxyethoxymethyl] guanine) is an acyclic nucleoside analogue of guanosine which is a potent and selective antiviral agent. acycloviris converted to the monophosphate by thymidine kinase the virus-specific form of this enzyme and is subsequently converted to the triphosphate by the host cell kinase. acyclovir triphosphate inhibits viral dna-polymerase terminating the chain and...

ulcerative colitis (uc) is one type of inflammatory bowel disease (ibd). herpes viruses have been suggested as possible etiological agents of uc and crohn’s disease (cd). the aim of this study was to investigate the prevalence of herpes simplex virus (hsv), cytomegalovirus (cmv) and epstein-barr virus (ebv) in patients with uc in comparison with healthy subjects by using pcr technique. in this ...

Background and Aims: Herpes simplex virus type 1 (HSV-1) belonging to herpes viridae family is a normal human pathogen with benign lesions in immunocompromised patients which creates serious problems. Acyclovir is used to treat herpetic infections. Because of developing drug-resistant strains, the use of medicinal plants and their related compounds with fewer side effects is considered for the ...

brown alga, turbinaria conoides was successively extracted with n-hexane, cyclohexane, methanol and ethanol:water (1:1). the extracts were evaluated for antibacterial and antifungal activities by disc diffusion method. minimal inhibitory concentration was determined for active extracts by broth dilution method. the antiviral activity and cytotoxicity of the extracts were tested in human embryon...

background and objectives: febrile convulsion is a common disorder in children. viral infections such as human herpes virus 6 (hhv-6) which results in roseola infantum may contribute to developing seizure. the objective of this study was to determine the prevalence of hhv-6 by detecting dna in cerebrospinal fluid (csf) of children with febrile convulsion and without any rash of roseola infantum...

objective herpes simplex virus (hsv) infection during pregnancy may lead to fetal loss. the aim of this study was to explore the infection rate of hsv type 1 and 2 infection associated with spontaneous abortion in a pilot case-control study in two cities of iran in 2010. patients and methods placenta and curettage samples from 35 healthy full term neonates and 35 cases of spontaneous abortion w...

background herpes simplex virus type 1 and type 2 (hsv-1 and hsv-2) are common infectious agents worldwide. data on prevalence of hsv-1 and hsv-2 infections are limited in asia, especially in iran. our study aimed on determination of seroepidemiology of hsv-1 and hsv-2 infections in asymptomatic healthy students of islamic azad university of kazeroun, fars province, southwest of iran. patients ...

background and objectives:  the molecular genetic of the human herpes virus 8 (hhv8) has now been characterized the pathogenesis of kaposi sarcoma (ks). this study attempted to determine the rate of hhu-8 infection in ks in an iraniann cross sectional study. method & material: in this cross-sectional study, we used paraffin-embedded specimens of 54 clinically well-characterized kaposi sarco...

The replication of herpes simplex virus type I and herpes simplex virus type 2 was studied in two isolated hamster cell lines. These lines developed after being treated with herpes simplex virus type 2 inactivated with 7,~2-dimethylbenz(a)anthracene. One cell line that developed, HDC-22, had a hypodiploid chromosome number and was missing a D-group chromosome. Growth studies revealed that this ...

PURPOSE This study determined the seroprevalence of herpes virus 2 in gravidas and the differences between herpes virus 2-infected and healthy gravidas. The need to screen gravidas for herpes virus 2 was also evaluated. MATERIALS AND METHODS A retrospective analysis involving 500 gravidas who underwent herpes virus 2 serologic testing and delivery in our hospital between January 2009 and Augu...