In the crystal structure of the title coordination polymer/co-crystal, {[ZnCl(2)(C(18)H(18)N(4))]·C(18)H(18)N(4)}(n), the tetrahedrally coordinated Zn(II) ions are linked by the N-heterocycle into a linear chain. Another N-heterocycle present is not coordinated to the metal atom but inter-acts with the chain through N-H⋯N and N-H⋯Cl hydrogen bonds. The butyl chain of the uncoordinated ligand is...

1. Student: Joyce Biaco Major: Chemistry Mentor: Timothy Barker Department: Chemistry and Biochemistry Title: Lewis Acid-Catalyzed Minisci Reactions Many pharmaceutical drugs contain at least one nitrogen atom. If that nitrogen atom is part of a ring with carbon atoms it is called a heterocycle. The ability to easily modify a heterocycle is useful to medicinal chemists because they are then abl...

The conformationally restricted adenine nucleotide analogs 8,3'anhydro-8-oxy-9-(beta-D-xylofuranosyl)adenine-5'-O-tri(di)-phosphate (I), and 8,2'-anhydro-8-oxy-9-(beta-D-arabinofuranosyl) adenine-5'-O-tri(di)-phosphate (II), were prepared chemically as their alpha-32P-labelled compounds and compared with syn-structured 8-bromo AT(D)P in mitochondrial adenine nucleotide translocation. The experi...

The notoriously non-selective aryl-diazonium surface-functionnalization turned selective in the presence of electron-deficient heterocycle. electro-activation probe allowed rapid and nearly quantitative liberation covalently tethered ligands.

Nitromethylene heterocycle insecticides are known to act on the nicotinic acetylcholine receptor-channel. The effects of the nitromethylene heterocycle, imidacloprid, on the nicotinic acetylcholine receptor-channel of clonal rat phaeochromocytoma (PC12) cells were studied using whole-cell and single-channel patch clamp methods. Imidacloprid suppressed carbachol-induced whole-cell currents in a ...

A new Pd-catalyzed one-pot multicomponent coupling reaction for the construction of benzene ring fused with carbocycle or heterocycle under a Cu-free condition is described.

The solid state interaction of mono and macromolecular thiols at a disulfide heterocycle is shown to provide a versatile pathway for their speciation.