Pd/C in HFIP was used to hydrogenate indole derivatives under relatively mild conditions, leading to potential synthetic intermediates of bioactive compounds. Depending on their substitution, tetrahydroindoles or octahydroindoles could selectively be obtained.

Direct monomethylation of primary amines with methyl triflate was achieved with high selectivity (up to 96%). The key point of this single methyl transfer stems from the use of HFIP as the solvent that interferes with amines and avoids overmethylation.

Multivariate regression based on partial least squares (PLS2) was applied to estimating one spectral dataset from another set having an intrinsic relationship with each other. An estimation was successfully carried out between mid-infrared (IR) spectra in the range of 2980 - 3800 cm(-1) and that of near-infrared (NIR) spectra in the range of 6000 - 7500 cm(-1) for hexafluoroisopropanol (HFIP)-w...

The specific rates of solvolysis (including those obtained from the literature) of isopropenyl chloroformate (1) are analyzed using the extended Grunwald-Winstein equation, involving the N(T) scale of solvent nucleophilicity (S-methyldibenzothiophenium ion) combined with a Y(Cl) scale based on 1-adamantyl chloride solvolysis. A similarity model approach, using phenyl chloroformate solvolyses fo...

The specific rates of solvolysis of neopentyl chloroformate (1) have been determined in 21 pure and binary solvents at 45.0 °C. In most solvents the values are essentially identical to those for ethyl and n-propyl chloroformates. However, in aqueous-1,1,1,3,3,3-hexafluoro-2-propanol mixtures (HFIP) rich in fluoroalcohol, 1 solvolyses appreciably faster than the other two substrates. Linear free...

The front cover picture is an artistic illustration of gold associated with HFIP, represented by a golden ball surrounded banner. This Au/HFIP duo efficiently transformed alkynylnaphthaldehydes to major trans tricyclic derivatives, according 6-enolendo-exo-trig pathway. Scope and limitations as well mechanistic studies for this rearrangement process were described leading functionalized ketones...

Magnesium batteries are one of the most promising post-lithium technologies. One main challenges preventing its commercialization is to find an efficient and safe electrolyte. The electrolyte, playing role blood in a battery, interacts with all battery components must be highly compatible them. development Cl-free electrolyte systems desired avoid corrosion issues, many studies suggest magnesiu...

Title: Improved techniques for protein analysis focusing on membrane proteins and hydrophobic peptides. Written in English by Theres Redeby, Division of Analytical Chemistry, Department of Chemistry, School of Chemical Science and Engineering, Royal Institute of Technology (KTH), SE-100 44 Stockholm, Sweden. In this thesis, the vital cell functions performed by integral membrane proteins (IMPs)...

The synthesis of 8-aminoquinolines and 1,10-phenanthrolines with substituents in α of the nitrogen has been performed through an inverse-demanding aza-Diels-Alder (Povarov reaction) in the fluoroalcohols TFE or HFIP. This path involves simple starting materials: 1,2-phenylenediamines, enol ethers and aldehydes.