Apelin is a recently discovered bioactive peptide, known to be an endogenous high-affinity ligandfor the previously orphan G protein-coupled receptor APJ. Apelin/APJ as a novel signaling pathwayhas been shown to play many crucial roles in cardiovascular function, blood pressure regulation, fluidhomeostasis, feeding behavior, obesity, type 2 diabetes mellitus, adipoinsular axis regulation, cellp...

Autism Spectrum Disorder (ASD) is a developmental disability that can create significant behavioral and communication challenges. The prevalence of ASD among children at 8 years age over 2%, the similar across ethnic groups countries. Studies have shown majority make an autoantibody to high-affinity folate receptor in response dietary component. This Folate Receptor Antibody (FRA) blocks transp...

The properties of ligand binding to the beta-adrenergic receptor have been studied using a computer modeling technique to analyze data obtained by indirect binding methods. Antagonists are shown to bind to the receptor with one homogeneous state of uniform affinity, while agonists manifest heterogeneous binding. For agonists, two distinct binding states are apparent; one of high and one of low ...

In silico designed peptides showed high binding affinity towards activated human hepatic stellate cells, offering new strategies to target insulin-like growth factor 2 receptor in fibrotic liver and suggesting a potential for noninvasive diagnosis.

Ligand-induced receptor oligomerization is an established mechanism for receptor tyrosine kinase activation. However, numerous receptor tyrosine kinases are expressed in multicomponent complexes with other receptors that may signal independently or alter the binding characteristics of the receptor tyrosine kinase. NGF interacts with two structurally unrelated receptors, the Trk A receptor tyros...

Activation or inhibition of hypothalamic GABAergic activity and immunopotentiation or immunosuppression during aging depends on the variation of the amount of dietary protein as well as the duration of its supplementation. Here we evaluate the effect of low (5%) and high (40%) protein diet on the functional state of hypothalamic GABA receptor in the aging brain in albino rats. Consumption of lo...

  Introduction: It has been shown that some primary human tumors and their metastases, including prostate and breast tumors, over-express gastrin-releasing peptide (GRP) receptors. Bombesin is a neuropeptide with a high affinity for these GRP receptors. The purpose of this study was to prepare and evaluate the characteristics of a new Freeze-dried kit, [6-hydrazinopyr...