In order to further delineate the mechanisms underlying genetic unresponsiveness, tetraparental mice were constructed from immune response-1A gene high responder and low responder parental genotypes, then were immunized with poly-L-(Tyr,Glu)-poly-D,L-Ala--poly-L-Lys ((T,G)-A--L). An analysis of the total serum allotype mixture and of the antigen-binding capacity of the separated allotypes demon...

Immunization of rabbits from a closed colony with streptococcal Group A-variant vaccines identified about two-thirds of them as low and heterogeneous responders. One-third of the rabbits showed a restriction of the response independent from the magnitude. Selective breeding from one monoclonal high-responder male and two restricted high-responder female rabbits succeeded in segregation of high-...

The immune response to certain synthetic polypeptide antigens and native proteins has been shown to be controlled by immune response (Ir) genes, which reside in the murine major histoeompatibility complex (MHC) 1 (reviewed in 1). The expression of such Ir gene control has been localized to T cells, B cells, and/or antigen-presenting cells (2-4). Support for the concept of Ir gene expression in ...

A proportion of healthy neonates and adults fail to develop a protective antibody response to recombinant hepatitis B (HB) vaccine. Unresponsiveness to vaccination could be attributed to defect in a number of immunological regulatory mechanisms. In this study, IL-12 was quantitated in culture supernatant following in vitro stimulation of peripheral blood mononuclear cells isolated from a group ...

Biologic TNFα inhibitors are a mainstay treatment option for patients with rheumatoid arthritis (RA) refractory to other treatment options. However, many patients either do not respond or relapse after initially responding to these agents. This study was carried out to identify biomarkers that can distinguish responder from non-responder patients before the initiation of treatment. The level of...

in vitro lymphocyte responses of high responder (hr) and low responder (lr) guinea pigs from pe-ripheral blood lymphocytes (pbl) to parasite antigens soluble protein third stage larvae (spl3) and soluble protein adult stage ( spa), non-parasite antigen ovalbumin (ova) were examined. there was substantial differences between hr and lr guinea pigs in the rate of acquisition of responsiveness to t...

The level of antibody produced in response to calf skin collagen in mice is influenced by genes which are closely linked to the I region of the H-2 major histocompatibility complex. This influence is shown to be expressed during lymphoid maturation by testing the antibody responsiveness to collagen in two types of chimeric mice. First, high responder and low responder parental strain mice were ...

BACKGROUND There have been few clinical studies on 10 mg atorvastatin as a starting dosage for treatment of hypercholesterolemia in type 2 diabetes mellitus (T2DM) patients. This retrospective study aims to evaluate the efficacy of 10 mg dosage of atorvastatin in clinical setting. METHODS One hundred five enrolled patients with high levels of low density lipoprotein cholesterol (LDL-C, > 100 ...

We have studied the properties of helper T cells specific for sheep erythrocytes (SRBC), keyhole limpet hemocyanin (KLH), or poly-L-(Tyr,Glu)-poly-DL-Ala-poly-L-Lys [(T,G)-A--L]. These T cells differentiated and were primed in vivo in irradiation chimeras constructed of various combinations of F1 and parental bone marrow donors and irradiated recipients. Primed T cells were then tested for help...

The immune response to certain synthetic polypeptide antigens and native proteins has been shown to be controlled by immune response (Ir) genes, which reside in the murine major histoeompatibility complex (MHC) 1 (reviewed in 1). The expression of such Ir gene control has been localized to T cells, B cells, and/or antigen-presenting cells (2-4). Support for the concept of Ir gene expression in ...