Jørgensen, A.C., 2004. Increasing process understanding of wet granulation by spectroscopic methods and dimension reduction tools Dissertationes Biocentri Viikki Universitatis Helsingiensis, 20/2004, 62 pp. ISBN 952-10-1955-7 ISBN 952-10-1956-5 (pdf) ISSN 1239-9469 Wet granulation is a common unit operation applied in the pharmaceutical industry. It is a complex process where several interrelat...

Breakthrough energy savings were recently projected by a spray-dryer free dairy powder manufacturing process based on superconcentration and granulation. The extent of the recirculation rate for granulation, determines performance. In this study, evolution physical properties during granulation was investigated model system (skim milk microfiltrate) using rheological shear-cell techniques. Resu...

Aims The X-ray micro-tomography (micro-CT) technique has been used to visualize the microstructure of pharmaceutical granules produced by high shear wet granulation and the dynamic evolution of porosity during granule dissolution. The combination of time-resolved micro-CT imaging with UV/VIS detection of the quantity dissolved made it possible to evaluate the effective diffusion coefficient of ...

During wet granulation, the sample can be exposed to considerable mechanical effects, moisture content and elevated temperatures, during high-shear granulation impeller chopper speeds induce temperatures influence parameters of products. In our work, we therefore aimed investigate effect cooling process on product by factorial design in accordance with QbD guidelines. Our other goal was study t...

In recent years, the interest in melt granulation has increased due to the advantages of this technique respect to traditional wet granulation; utilizable equipments for melt granulation are high-shear mixer and fluidised bed [1]. The aim of the study was to evaluate, by asymmetrical factorial design [2], the contribution of some variables on the in situ melt granulation process performed in fl...

The continuous shear roll milling can be used for the processing and granulation of gun propellants. Here a mathematical model of the continuous shear roll milling process will be presented along with experimental data collected on live and simulant propellant formulations. The role of the flow boundary condition will be shown to be critical in the processability analysis. The safety aspects wi...