X. Xu, M. Al-Ghabeish, Y. S. Krishnaiah, Z. Rahman, M. A. Khan U.S. Food and Drug Administration Purpose From a drug product quality perspective, in vitro release testing (IVRT) serves many different, yet crucial roles throughout the lifecycle of a drug product. Unfortunately, the maturity of IVRT methods for pharmaceutical ointments is considerably lacking and under-utilized as compared to con...

<span lang="EN-GB">Lung sound is one indicator of abnormalities in the lungs and respiratory tract. Research for automatic lung classification has become interests researchers because disease diseases with most sufferers world. The use sounds as a source information ease data acquisition auscultation standard method examining pulmonary function. This study simulated potential Higuchi frac...

Objective: The objective of the present work was to formulate a gastroretentive dosage form of Valacyclovir, an anti viral drug. Methods: Valacyclovir gastroretentive mucoadhesive tablets were prepared using polymers such as Carbopol 974P and hydroxy propyl methyl cellulose (HPMC) K4M, in different proportions by wet granulation technique. Compatibility studies were performed by FTIR spectrosco...

A sustained-release tablet formulation should ideally have a proper release profile insensitive to moderate changes in tablet hardness that is usually encountered in manufacturing. In this study, matrix aspirin (acetylsalicylic acid) tablets with ethylcellulose (EC), Eudragit RS100 (RS), and Eudragit S100 (S) were prepared by direct compression. The release behaviors were then studied in two co...

In this paper the boundary conditions for point defect distributions in monocrystalline silicon are investigated. These boundary conditions are established by simple thermodynamic considerations. A circle process is used including vacancy, interstitial and Frenkel pair generation which yields a simple relationship between the vacancy and interstitial equilibrium concentrations at the surface. A...

*Research Scholar Department of Pharmacy, School of Medical and Allied Sciences Galgotias University, Gautam Buddh Nagar, Greater Noida (U.P.) e-mail: [email protected] Abstract: The objective of the present study was to develop floating microspheres of Gliclazide in order to achieve an extended retention in the upper gastrointestinal tract, which may result in enhanced absorption a...

Quantitative applications of the Polymerase Chain Reaction (PCR), also known as Quantitative-PCR (Q-PCR) are intended either to determine the number of copies of a given nucleic acid sequence, or more generally, to determine the relative abundance of two sequences. Current methods to determine exact numbers of molecules overcome the determination of the amplification rate by assuming identical ...

The “anomalous solubility behavior at higher pH values” of several acidic drugs originally studied by Higuchi et al. in 1953 [1], but hitherto not fully rationalized, has been re-analyzed using a novel solubilitypH analysis computer program, pDISOL-X TM . The program internally derives implicit solubility equations, given a set of proposed equilibria and constants (iteratively refined by weight...