Pyramidal cells in the rodent hippocampus often exhibit clear spatial tuning. Theories of hippocampal function suggest that these "place cells" implement multiple, independent neural representations of position (maps), based on different reference frames or environmental features. Consistent with the "multiple maps" theory, previous studies have shown that manipulating spatial factors related t...

Cell adhesion molecules (CAMs) play important roles during the development of the nervous system. On the basis of our previous observations that binding of the neural CAM (N-CAM) inhibits astrocyte proliferation and alters gene expression, we hypothesized that N-CAM may influence the balance between the proliferation and the differentiation of neural progenitor cells. Rat and mouse hippocampal ...

epilepsy is one of the most common neuroinflammatory disorders that affect more than 50 million people worldwide. excessive electrical discharges in neurons following neural cell damage or loss leads to recurrent seizures, which are described as epilepsy. one of the most common and difficult to treat types of epilepsy is temporal lobe epilepsy (tle), which results from hippocampal sclerosis. cu...

Neural stem cells have the capacity to self-renew, proliferate, and give rise to lineage-restricted neuronal and/or glial progenitor cells and postmitotic specialized daughter cells. Neural progenitor cells located in the subgranular zone (SGZ) of the dentate gyrus (DG) give rise to immature neurons. These then migrate to the granule cell layer, where they differentiate into granule neurons tha...

Adult hippocampal neurogenesis is a highly plastic process that responds swiftly to neuronal activity. Adult hippocampal neurogenesis can be regulated at the level of neural stem cell recruitment and activation, progenitor proliferation, as well as newborn cell survival and differentiation. An "excitation-neurogenesis" rule was proposed after the demonstration of the capability of cultured neur...

1. Abstract 2. Introduction 3. Adult neural stem cells and neurogenesis 3.1. Hippocampal stem cells 3.2. Subventricular zone (SVZ) and olfactory bulb stem cells 3.3. Progenitors derived from non-neurogenic regions 3.4. Adult neural stem cell engraftment in vivo 3.4.1. Hippocampal derived neural stem cells 3.4.2. SVZ derived neural stem cells 3.4.3. Spinal cord progenitors 3.4.4. Cortical derive...

Hippocampal neural systems consolidate multiple complex behaviors into memory. However, the temporal structure of neural firing supporting complex memory consolidation is unknown. Replay of hippocampal place cells during sleep supports the view that a simple repetitive behavior modifies sleep firing dynamics, but does not explain how multiple episodes could be integrated into associative networ...

The ERK/MAPK pathway is an important developmental signaling pathway. Mutations in upstream elements of this pathway result in neuro-cardio-facial cutaneous (NCFC) syndromes, which are typified by impaired neurocognitive abilities that are reliant upon hippocampal function. The role of ERK signaling during hippocampal development has not been examined and may provide critical insight into the c...