A fundamental property of the immune system is its ability to mediate self-defense with a minimal amount of collateral damage to the host. The system uses several different mechanisms to achieve this goal, which is collectively referred to as the "process of immunological tolerance." This article provides an introductory historical overview to these various mechanisms, which are discussed in gr...

When designing hardware systems, a variety of models and languages are available whose aim is to manage complexity by allowing specification of such systems at different abstraction levels. Languages such as Verilog and VHDL where designed with simulation in mind rather than synthesis and lack features such as parametrised complex circuit definitions, a must for the design of generic complex sy...

Inhalational agents have played a pivotal role in anesthesia history. The first publicly demonstrated anesthetic of the modern era, diethyl ether, was an inhalational anesthetic. The attributes of a good agent, ability to rapidly induce anesthesia, with limited side effects has led research efforts for over a hundred and fifty years. The explosion hazard was largely conquered with the developme...