Background: Human leukocyte antigens (HLA) are polymorphic cell surface proteins. Distribution of HLA alleles vary among different racial and ethnic populations in unrelated stem cell registries. Determination of HLA allele frequencies in different ethnic groups is useful for population genetic analyses. Materials and Methods: Based on data available from the Iranian Stem Cell Donor Registry...

This study was aimed to evaluate the influence of Human Leukocyte Antigens- G (HLA-G) gene polymorphisms on risk rheumatoid arthritis (RA). In present study, blood samples were collected from 100 patients and healthy controls. Serum levels HLA-G in both controls measured using ELISA kit which shown a higher significant differences (p< 0.05) comparison between them (539.3 ng/ml 139.3ng/ml) re...

We studied the expression of major histocompatibility complex class I antigens in 59 bronchogenic carcinomas, as well as in pneumocytes and epithelial respiratory cells distant from the tumor. We observed in all cases that normal lung tissue expressed major histocompatibility complex class I antigens, while this expression was completely lost in 16 tumors (27%). The defect in HLA gene expressio...

A N UNDERSTANDING of the structure of human platelet membrane antigens is of both biologic’ and clinical7 interest. HLA-A,B antigens’ and those of the ABH system2 are present on platelets. However, adsorption of exogenous soluble HLA-A,B antigens34 and ABH substances5 onto platelets has been demonstrated in vitro. This raises the question of whether these antigens are integral membrane proteins...

The aim of the study was to examine frequencies of HLA-A, -B, -DR antigens and haplotypes in population of Rijeka and to compare them with general Croatian and European populations. The subjects were 117 unrelated healthy blood donors. The antigens with the highest frequencies were: A2 (27.2%), A9 (16.3%), B5 (14.8%), B12 (11.8%), B18 (11.8%), DR5 (21.6%) and DR6 (13.8%). Comparison of HLA anti...

in addition to ultrasonographic monitoring of folliculogenesis, urinary luteinizing hormone testing, luteal phase endometrial biopsy, serum antiphospholipid antibodies, etc., immunologic tests are recently being used to evaluate reproductive disorders. in this study, sharing of hla-a, b, c and dr antigens and the presence of antipaternal cytotoxic antibody (apca) was assessed using microcytotox...

We examined the expression of HLA-DR and HLA-DQ antigens and mRNA from myeloid and lymphoid cells obtained from normal volunteers and established cell lines. Cytofluorometric analysis and immunoprecipitation were performed using murine monoclonal antibodies specific for HLA-DR (L-243) and HLA-DQ (Leu 10). The expression of mRNA for HLA-DR and HLA-DQ chains was determined by Northern blot and RN...

Background: Miscarriage is a common phenomenon complicating more than half of pregnancies. Recurrent Pregnancy Loss (RPL) is defined as three or more pregnancies lost before the twentieth week of gestation. It is believed that abnormality in maternal immune reaction to fetus and sharing of HLA antigens might be associated with RPL. Objective: To investigate the effect of HLA-DRB1 sharing betwee...

Thrombocytes from HLA-A1 and HLA-A2 negative donors were incubated with plasma obtained from respective HLA-positive donors. The plasma-treated thrombocytes were shown to acquire HLA specificity of the plasma as demonstrated by their ability to absorb lymphocytotoxic activity of monospecific anti-HLA sera. The data are consistent with the hypothesis that the expression of HLA antigens in cells ...

the turkmans are one of the iranian ethnic population. hla typing (class i and ii) was performed in this population. the data obtained from this study was compared with different populations of the world. we observed that the turkman population is most similar to the northern chinese and uigur population. the distributions of hla antigens in turkmans are somewhat between iranian population, nor...